Fate of the mammalian cardiac neural crest.
- X. Jiang, D. Rowitch, Philippe Soriano, A. McMahon, H. Sucov
- 15 April 2000
A two-component genetic system based on Cre/lox recombination is employed to label indelibly the entire mouse neural crest population at the time of its formation, and to detect it at any time thereafter.
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
It is demonstrated, for the first time, that CNC cells contribute to the formation of condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel's cartilage, mandible, the articulating disc of temporomandibular joint and branchial arch nerve ganglia.
Tissue origins and interactions in the mammalian skull vault.
- Xiaobing Jiang, S. Iseki, R. Maxson, H. Sucov, G. Morriss-Kay
- Biology, MedicineDevelopmental Biology
Detailed analysis of neural crest migration pathways using X-gal staining, and mesodermal tracing by DiI labelling, shows that the neural crest-mesodermal tissue juxtaposition that later forms the coronal suture is established at E9.5 as the caudal boundary of the frontonasal mesenchyme.
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
- H. Sucov, E. Dyson, C. L. Gumeringer, J. Price, K. Chien, R. Evans
- Biology, MedicineGenes & Development
- 1 May 1994
These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways.
Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
- Xiantuo Wu, Jian Wu, P. Roy‐Burman
- BiologyMechanisms of Development
- 1 March 2001
An Essential Role for Retinoid Receptors RARβ and RXRγ In Long-Term Potentiation and Depression
Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.
- H. Sucov, K. Murakami, R. Evans
- BiologyProceedings of the National Academy of Sciences…
- 1 July 1990
Surprisingly, a high level of retinoic acid-dependent activation was seen in the absence of transfected RAR in 10 of 10 vertebrate cell lines, many functionally characterized previously as lacking endogenous receptor.
IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development
- Peng Li, S. Cavallero, H. Sucov
- Biology, MedicineDevelopment
- 1 May 2011
It is confirmed that IGF signaling is required to activate the ERK proliferation pathway in the developing heart, and that the epicardium is required for this response.
Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
- M. Ishii, Jun Han, Hai-Yun Yen, H. Sucov, Y. Chai, R. Maxson
- Biology, MedicineDevelopment
- 12 October 2005
It is shown that Msx1/2 mutants exhibit profound deficiencies in the development of structures derived from the cranial and cardiac neural crest, including hypoplastic and mispatterned cranial ganglia, dysmorphogenesis of pharyngeal arch derivatives and abnormal organization of conotruncal structures in the developing heart.
Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault
- M. Ishii, Amy E. Merrill, R. Maxson
- 15 December 2003
It is demonstrated that heterozygous loss of Twist function causes a foramen in the skull vault similar to that caused by loss of Msx2 function, and that both the quantity and proliferation of the frontal bone skeletogenic mesenchyme are reduced inMsx2-Twist double mutants compared with individual mutants.