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Fate of the mammalian cardiac neural crest.
A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalianExpand
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Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
Neural crest cells are multipotential stem cells that contribute extensively to vertebrate development and give rise to various cell and tissue types. Determination of the fate of mammalian neuralExpand
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Tissue origins and interactions in the mammalian skull vault.
During mammalian evolution, expansion of the cerebral hemispheres was accompanied by expansion of the frontal and parietal bones of the skull vault and deployment of the coronal (fronto-parietal) andExpand
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Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
To facilitate the elucidation of the genetic events that may play an important role in the development or tumorigenesis of the prostate gland, we have generated a transgenic mouse line withExpand
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RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
We have established a targeted loss-of-function mutation in the RXR alpha gene in the mouse germ line that results in embryonic lethality between E13.5 and E16.5 when bred to homozygosity. The majorExpand
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An Essential Role for Retinoid Receptors RARβ and RXRγ In Long-Term Potentiation and Depression
Abstract Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. We reportExpand
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Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.
A sequence that confers transcriptional responsiveness to retinoic acid was identified in the promoter of the mouse retinoic acid receptor (RAR) beta gene. This response element consists of a directExpand
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Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver
ABSTRACT A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we haveExpand
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IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development
Secreted factors from the epicardium are believed to be important in directing heart ventricular cardiomyocyte proliferation and morphogenesis, although the specific factors involved have not beenExpand
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Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
The neural crest is a multipotent, migratory cell population that contributes to a variety of tissues and organs during vertebrate embryogenesis. Here, we focus on the function of Msx1 and Msx2,Expand
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