Ligand Binding Domain

Known as: Binding Site, Binding Site Domain, ligand-binding domain 
A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Seventy percent of breast cancers express estrogen receptor (ER), and most of these are sensitive to ER inhibition. However, many… (More)
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Highly Cited
2009
Highly Cited
2009
Suppression of androgen production and function provides palliation but not cure in men with prostate cancer (PCa). Therapeutic… (More)
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Highly Cited
2005
Highly Cited
2005
MOTIVATION Identifying the location of ligand binding sites on a protein is of fundamental importance for a range of applications… (More)
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Review
2002
Review
2002
The ligand binding domain (LBD) of the nicotinic acetylcholine receptor has served as a prototype for understanding molecular… (More)
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Highly Cited
2002
Highly Cited
2002
The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which… (More)
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Highly Cited
2001
Highly Cited
2001
Pentameric ligand gated ion-channels, or Cys-loop receptors, mediate rapid chemical transmission of signals. This superfamily of… (More)
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Highly Cited
1998
Highly Cited
1998
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent transcription factor that is important in… (More)
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Highly Cited
1997
Highly Cited
1997
Ligand-dependent chimeric Cre recombinases are powerful tools to induce specific DNA rearrangements in cultured cells and in mice… (More)
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Highly Cited
1995
Highly Cited
1995
A number of proteins have been rendered functionally oestrogen-dependent by fusion with the hormone-binding domain of the… (More)
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Highly Cited
1995
Highly Cited
1995
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an… (More)
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