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Ligand Binding Domain

Known as: Binding Site, Binding Site Domain, ligand-binding domain 
A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four… Expand
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Highly Cited
2013
Highly Cited
2013
Seventy percent of breast cancers express estrogen receptor (ER), and most of these are sensitive to ER inhibition. However, many… Expand
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Highly Cited
2001
Highly Cited
2001
Pentameric ligand gated ion-channels, or Cys-loop receptors, mediate rapid chemical transmission of signals. This superfamily of… Expand
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Highly Cited
2001
Highly Cited
2001
Distinct modifications of histone amino termini, such as acetylation, phosphorylation and methylation, have been proposed to… Expand
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Highly Cited
1999
Highly Cited
1999
Oestrogens exert their physiological effects through two receptor subtypes. Here we report the three‐dimensional structure of the… Expand
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Highly Cited
1998
Highly Cited
1998
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent transcription factor that is important in… Expand
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Highly Cited
1997
Highly Cited
1997
Ligand-dependent chimeric Cre recombinases are powerful tools to induce specific DNA rearrangements in cultured cells and in mice… Expand
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Highly Cited
1995
Highly Cited
1995
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an… Expand
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Highly Cited
1995
Highly Cited
1995
The 2.0-Å crystal structure of the ligand-binding domain (LBD) of the human retinoic acid receptor (RAR)-γ bound to all-trans… Expand
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Highly Cited
1995
Highly Cited
1995
A number of proteins have been rendered functionally oestrogen-dependent by fusion with the hormone-binding domain of the… Expand
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