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Ligand Binding Domain

Known as: Binding Site, Binding Site Domain, ligand-binding domain 
A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand… 
National Institutes of Health

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Broader (2)

Binding Sitesreceptor

Papers overview

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Highly Cited
2003
Highly Cited
2003
Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity
ABSTRACT The actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which is activated upon ligand binding… 
Highly Cited
2002
Highly Cited
2002
A model for the functioning of family 3 GPCRs.
Highly Cited
2001
Highly Cited
2001
The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation.
Ultraspiracle (USP) is the invertebrate homologue of the mammalian retinoid X receptor (RXR). RXR plays a uniquely important role… 
Highly Cited
1999
Highly Cited
1999
Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression.
Mechanisms of regulation of mouse metallothionein (MT)-I gene expression in response to bacterial endotoxin-lipopolysaccharide… 
Highly Cited
1994
Highly Cited
1994
EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1
The EBNA-2 protein is essential for the establishment of a latent Epstein-Barr virus (EBV) infection and for B-cell… 
Highly Cited
1993
Highly Cited
1993
Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.
Dynamin is a 100-kDa GTPase that plays a critical role in the initial stages of endocytosis. Dynamin binds to microtubules, which… 
Highly Cited
1990
Highly Cited
1990
Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain
The 70-kilodalton heat shock protein (hsp70) family members appear to be essential components in a number cellular protein… 
Highly Cited
1988
Highly Cited
1988
The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case.
A weak Ca2+ binding site in the bacterial serine protease subtilisin BPN' (EC 3.4.21.14) was chosen as a model to explore the… 
Highly Cited
1983
Highly Cited
1983
Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine.
The binding of the platelet-activating factor 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC) by human… 
Highly Cited
1982
Highly Cited
1982
The interaction of vanadate ions with the Ca-ATPase from sarcoplasmic reticulum.
The interaction of vanadate ions with the Ca-ATPase from sarcoplasmic reticulum vesicles was studied in a native and a… 
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