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Novel Signal Transduction Pathway Utilized by Extracellular HSP70
TLDR
It is demonstrated that exogenously added HSP70 possesses potent cytokine activity, with the ability to bind with high affinity to the plasma membrane, elicit a rapid intracellular Ca2+ flux, activate NF-κB, and up-regulate the expression of pro-inflammatory cytokines in human monocytes. Expand
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
TLDR
Findings indicate that CD14 is a co-receptor for HSP70-mediated signaling in human monocytes and are indicative of an previously unrecognized function for H SP70 as an extracellular protein with regulatory effects on human monocyte, having a dual role as chaperone and cytokine. Expand
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
TLDR
Although Hsp levels are not informative at the diagnostic level, they are useful biomarkers for carcinogenesis in some tissues and signal the degree of differentiation and the aggressiveness of some cancers. Expand
Heat shock proteins in cancer: chaperones of tumorigenesis.
TLDR
The heat shock proteins have thus become targets for rational anti-cancer drug design: HSP90 inhibitors are currently showing much promise in clinical trials, whereas the increased expression of HSPs in tumors is forming the basis of chaperone-based immunotherapy. Expand
Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1*
TLDR
Experiments indicate that MAPK is a potent inhibitor of HSF-1 function and may be involved in repressing the heat shock response during normal growth and development and deactivating the heatshock response during recovery from stress. Expand
mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis
TLDR
It is shown that mTOR in human tissue culture cells plays a key role in responses to proteotoxic stress and that reduction in mTOR levels by RNA interference leads to increase sensitivity to heat shock. Expand
The dual immunoregulatory roles of stress proteins.
TLDR
Conclusions regarding the immunobiology of these powerful immunomodulatory molecules must take into account their dichotomous properties and their physiological role and importance must be interpreted in the context of the complex in vivo microenvironments in which these proteins exist. Expand
Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes1
TLDR
The experiments suggest a mechanism for HSP70 secretion and binding to the surface of other cells that may be involved in recognition of the tumor cells by the immune system and a regulatory role for extracellular ATP. Expand
Heat Shock Factor 1 Represses Transcription of theIL-1β Gene through Physical Interaction with the Nuclear Factor of Interleukin 6*
TLDR
The studies show that HSF1 represses the lipopolyliposaccharide-induced transcription of the IL-1β promoter through direct interaction with the nuclear factor of interleukin 6 (NF-IL6, also known asCCAAT enhancer bindingprotein (C/EBPβ), an essential regulator inIL-1 β transcription. Expand
TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release
TLDR
In vivo and in vitro mechanistic studies suggest that transcription-coupled phosphorylation regulates Pol II pause release by TRIM28, which is identified as a new factor that modulates Pol II pausing and transcriptional elongation at a large number of mammalian genes. Expand
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