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The Partner of Inscuteable/Discs-Large Complex Is Required to Establish Planar Polarity during Asymmetric Cell Division in Drosophila
TLDR
The Dlg/Pins complex responds to Fz signaling to establish planar asymmetry in the pI cell and acts with Fz to localize Baz posteriorly, but Baz is not required to localise Pins anteriorly. Expand
Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding*
TLDR
A three-dimensional model of the LBP-like domain of the GABAB receptor was constructed based on the known structure of LBP and proposes that the initial step in the activation of the receptor by agonist results from the closure of the two lobes of the binding domain. Expand
Cloning and Functional Expression of a DrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS
TLDR
The cloning and functional characterization of an invertebrate metabotropic glutamate receptor isolated from Drosophila melanogaster indicates that the original structural features of both glutamate receptor types are conserved from insects to mammals and suggest that the functions of these receptors have been highly conserved during evolution. Expand
Shaggy, the Homolog of Glycogen Synthase Kinase 3, Controls Neuromuscular Junction Growth in Drosophila
TLDR
Drosophila homolog of the mammalian glycogen synthase kinases 3 α and β, two serine-threonine kinases, was concentrated at this synapse and it was found that Shaggy negatively controlled the NMJ growth. Expand
Rapsynoid/Partner of Inscuteable Controls Asymmetric Division of Larval Neuroblasts in Drosophila
TLDR
A new Drosophila protein, Rapsynoid (Raps), is described, which interacts in a two-hybrid assay with the signal transduction protein Galpha(i), and data show that Raps is a novel protein involved in the control of asymmetric divisions of neuroblasts. Expand
Glutamate and its metabotropic receptor in Drosophila clock neuron circuits
TLDR
It is shown that glutamate and its metabotropic receptor, DmGluRA, are components of the clock circuitry and modulate the rhythmic behavior pattern of Drosophila. Expand
The Drosophila Metabotropic Glutamate Receptor DmGluRA Regulates Activity-Dependent Synaptic Facilitation and Fine Synaptic Morphology
TLDR
It is shown here that DmGluRA is expressed at the glutamatergic neuromuscular junction (NMJ), localized in periactive zones of presynaptic boutons but excluded from active sites, and the following two roles are revealed: modulation of Presynaptic excitability properties important for the control of activity-dependent neurotransmitter release and modulation of synaptic architecture. Expand
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.
TLDR
It is reported that mGluR2 and mgluR4, two receptors negatively coupled to adenylyl cyclase, activate PLC when coexpressed with G alpha 15, G alpha ql or G alphaqo, indicating that the carboxyl-terminal end of the G alpha subunit also plays an important role in the specific interaction between mGLURs and the G proteins. Expand
Muscle Dystroglycan Organizes the Postsynapse and Regulates Presynaptic Neurotransmitter Release at the Drosophila Neuromuscular Junction
TLDR
A conservation of DGC composition and interactions between Drosophila and vertebrates at the synapse is illustrated, new proteins associated with this complex are highlighted and an unsuspected trans-synaptic function of Dg is suggested. Expand
Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila.
TLDR
How important is Tau phosphorylation for axonal transport and neurohormone release in vivo, using the Drosophila model is studied, and a stronger toxicity of hypophosphorylated Tau for neuronal function is demonstrated, revealing a potential limit of the current therapeutic strategy aimed at inhibiting Tauosphorylation. Expand
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