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Leukotriene B4

Known as: Leukotriene B 4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid, Leukotriene B4 [Chemical/Ingredient] 
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen… 
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (11)

12-methylleukotriene B312-oxoleukotriene B414,15-leukotriene B420-aldehyde leukotriene B4

Broader (2)

5,12-diHETELeukotrienes B
In BloodLeukotriene B4 MeasurementProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… 
Review
2006
Review
2006
Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.
  • A. Simopoulos
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 2006
  • Corpus ID: 15875656
Highly Cited
2003
Highly Cited
2003
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate… 
Highly Cited
2000
Highly Cited
2000
A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB(4… 
Highly Cited
2000
Highly Cited
2000
The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes
Review
1994
Review
1994
The Role of Leukotrienes in Inflammation
Leukotrienes, together with prostaglandins, thromboxanes, and lipoxins, are the major constituents of a group of biologically… 
Highly Cited
1990
Highly Cited
1990
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
The hypothesis that neutrophils play an important role in the pathogenesis of gastric ulceration induced by nonsteroidal anti… 
Highly Cited
1989
Highly Cited
1989
Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils.
Highly Cited
1983
Highly Cited
1983
Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.
Chemoattractant N-formylmethionylleucylphenylalanine (fMet-Leu-Phe) in the presence of cytochalasin B stimulates the release of… 
Highly Cited
1981
Highly Cited
1981
Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence.
We studied the effects of leukotrienes on in vitro functions of neutrophil polymorphonuclear (PMN) granulocytes. Leukotriene B4… 
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