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Leukotriene B4

Known as: Leukotriene B 4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid, Leukotriene B4 [Chemical/Ingredient] 
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen… 
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (11)

12-methylleukotriene B312-oxoleukotriene B414,15-leukotriene B420-aldehyde leukotriene B4

Broader (2)

5,12-diHETELeukotrienes B
In BloodLeukotriene B4 MeasurementProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo.
Highly Cited
1995
Highly Cited
1995
Induction of heat-shock protein 72 protects against ischemia/reperfusion in rat small intestine.
Review
1992
Review
1992
Designing therapeutically effective 5-lipoxygenase inhibitors.
Highly Cited
1988
Highly Cited
1988
Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells.
Mucosal mast cells (MMC) were isolated from the intestine of Nippostrongylus brasiliensis-infected rats and then activated with… 
Highly Cited
1987
Highly Cited
1987
Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin.
Because infiltration of mononuclear cells and fibroblast proliferation are associated in chronic inflammatory lesions, we tested… 
Highly Cited
1986
Highly Cited
1986
Development of cyclooxygenase and lipoxygenase metabolites of arachidonic acid after transient cerebral ischemia.
Vasoactive arachidonic acid metabolites are postulated to play a role in the pathogenesis of cerebral ischemia. In order to… 
Highly Cited
1985
Highly Cited
1985
Leukotrienes B4, C4 and D4 stimulate DNA synthesis in cultured human epidermal keratinocytes
Leukotrienes in psoriatic skin lesions are potent mediators of inflammation. We have studied the capacity of leukotrienes to… 
Highly Cited
1985
Highly Cited
1985
Allergen‐Induced Release of Sulphidopeptide Leukotrienes (SRS‐A) and LTB4 in Allergic Rhinitis
Leukotrienes are a recently discovered group of arachidonic acid‐derived lipid mediators. Using radioimmunoassay and high… 
Highly Cited
1983
Highly Cited
1983
Direct demonstration of increased intracellular concentration of free calcium in rabbit and human neutrophils following stimulation by chemotactic factor.
Highly Cited
1981
Highly Cited
1981
Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes.
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