Skip to search formSkip to main contentSkip to account menu

Leukotriene B4

Known as: Leukotriene B 4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid, Leukotriene B4 [Chemical/Ingredient] 
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen… 
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (11)

12-methylleukotriene B312-oxoleukotriene B414,15-leukotriene B420-aldehyde leukotriene B4

Broader (2)

5,12-diHETELeukotrienes B
In BloodLeukotriene B4 MeasurementProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1987
Highly Cited
1987
Inhibition by leukotriene B5 of leukotriene B4-induced activation of human keratinocytes and neutrophils.
Leukotriene B5 (LTB5) that is generated enzymatically from eicosapentaenoic acid (EPA), was compared with arachidonic acid… 
Highly Cited
1987
Highly Cited
1987
Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes.
Human mast cells, dispersed from lung tissue by proteolytic treatment and enriched to a purity of 23 to 68% by density-gradient… 
1986
1986
Enteral and systemic release of leukotrienes during anaphylaxis of Nippostrongylus brasiliensis-primed rats.
Rats with acquired immunity to the intestinal nematode Nippostrongylus brasiliensis develop anaphylaxis after i.v. challenge with… 
1986
1986
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
We have characterized the GTPase activity of the Ni-like guanine-nucleotide-binding regulatory protein in rabbit neutrophil… 
Highly Cited
1985
Highly Cited
1985
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
Human polymorphonuclear leukocytes (PMN) not only synthesize and respond to leukotriene B4 (LTB4), but also catabolize this… 
Highly Cited
1985
Highly Cited
1985
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
A single reaction product was formed during the incubation of 1.5 microM (5S,12R)-dihydroxy-6,14-cis-8,10-trans-[3H… 
Highly Cited
1984
Highly Cited
1984
Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats.
The generation of sulfidopeptide leukotrienes and leukotriene B (LTB) in response to an IgG-mediated immune complex reaction in… 
Highly Cited
1983
Highly Cited
1983
Increased monocyte chemotaxis towards leukotriene B4 and platelet activating factor in patients with inflammatory dermatoses.
In vitro monocyte chemotaxis towards leukotriene B4(LTB4) and platelet activating factor (PAF) was studied with cells from 51… 
Highly Cited
1983
Highly Cited
1983
Enhancement of human neutrophil adherence by synthetic leukotriene constituents of the slow-reacting substance of anaphylaxis.
The functionally predominant constituents of the slow-reacting substance of anaphylaxis (SRS-A), designated leukotrienes C4 and… 
Highly Cited
1981
Highly Cited
1981
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.
A rabbit immunized with a conjugate of leukotriene D4 (LTD4) and bovine albumin via the icosanoid carboxyl produced antibodies… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)