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5,12-diHETE

Known as: 5,12 HETE, 5,12 diHETE, 5,12-HETE 
 
National Institutes of Health

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Leukotriene B4

Papers overview

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2016
2016
Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa.
Pseudomonas aeruginosa expresses a secreted LOX-isoform (PA-LOX, LoxA) capable of oxidizing polyenoic fatty acids to hydroperoxy… Expand
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1999
1999
Platelet contribution to leukotriene production in inflammation: in vivo evidence in the rabbit.
The contribution of platelets to arachidonic acid transcellular metabolism may represent an important pathway of leukotriene (LT… Expand
1993
1993
Identification of 5-keto-(7E,9E,11Z,14Z)-eicosatetraenoic acid as a novel nonenzymatic rearrangement product of leukotriene A4.
Leukotriene A4 (LTA4), the reaction product of 5-lipoxygenase in human polymorphonuclear (PMN) leukocytes, is transformed both to… Expand
1990
1990
Interaction of 5-HETE, 12-HETE, 15-HETE and 5,12-diHETE at the human platelet thromboxane A2/prostaglandin H2 receptor.
A variety of lipoxygenase products such as 12- and 15-hydroxyeicosatetraenoic acid (12- and 15-HETE) inhibit thromboxane A2 (TXA2… Expand
1989
1989
Cutaneous inflammation: effects of hydroxy acids and eicosanoid pathway inhibitors on vascular permeability.
Four metabolic products of arachidonic acid lipoxygenation, 5-hydroxyeicosatetraenoate (5-HETE), 12-HETE, 15-HETE, 5(S),12(S… Expand
1985
1985
Increased activity of 5-lipoxygenase in polymorphonuclear leukocytes from asthmatic patients.
The formation of 5-lipoxygenase products of arachidonic acid, 5-HETE and 5,12-diHETE, was determined in 100,000 X g supernatant… Expand
1983
1983
Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.
Ten eicosanoid compounds (3, 6, 9, 11, 12, 15, 18, 21, 23, and 25), methyl (6E,8Z,11Z,14Z)-5-hydroxy-6,8,11,14-eicosatetraenoate… Expand
Highly Cited
1982
Highly Cited
1982
Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.
Neutrophils metabolize arachidonic acid through the liposygenase pathway to 5-hydroxy-6,8,11,14-eicosatetrenoic acid (5-HETE) and… Expand
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Highly Cited
1980
Highly Cited
1980
Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.
A number of hydroperoxy (HPETE) and hydroxy (HETE) products of the lipoxygenase pathway of arachidonic acid metabolism are… Expand
Highly Cited
1980
Highly Cited
1980
Fatty acid structural requirements for leukotriene biosynthesis.
Utilizing a variety of fatty acids, differing in chain length, degree and position of unsaturation, we investigated the substrate… Expand
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