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Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols.
- N. Brossard, M. Croset, C. Pachiaudi, J. Riou, J. Tayot, M. Lagarde
- BiologyThe American journal of clinical nutrition
- 1 October 1996
The occurrence of a weak basal 22:6n- 3 retroconversion in humans supports feeding this pure PUFA in cases in which 20:5n-3 presents undesirable side effects and when specific alterations of blood lipids are expected.
Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells[S]
Both in vivo and in vitro, intestinal absorption of 4-HHE was associated with formation of 4HHE-protein adducts and increased expression of glutathione peroxidase 2 (GPx2) and glucose-regulated protein 78 (GRP78) and triggers oxidative stress and inflammation in the upper intestine.
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat.
Substantial concentrations of 2-acyl-lysoPtdCho are present in plasma and are available for tissue uptake, where they can be reacylated at the sn-1 position to form membrane phospholipids.
Activation of p38 mitogen-activated protein kinase/cytosolic phospholipase A2 cascade in hydroperoxide-stressed platelets.
Small, Dense High-Density Lipoprotein-3 Particles Are Enriched in Negatively Charged Phospholipids: Relevance to Cellular Cholesterol Efflux, Antioxidative, Antithrombotic, Anti-Inflammatory, and…
The structure–function analysis reveals that the HDL lipidome may strongly affect atheroprotective functionality, reflecting enrichment of phosphatidylserine in small, dense HDL3.
Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation
Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina.
- T. Bisogno, I. Delton-Vandenbroucke, A. Milone, M. Lagarde, V. Di Marzo
- ChemistryArchives of biochemistry and biophysics
- 15 October 1999
Data indicate that AEA and its congeners may play a physiological role in the mammalian eye and it is found that isolated particulate fractions from bovine retina could release A EA and DHEA in a time-dependent fashion.
Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine.
- D. Lemaitre-Delaunay, C. Pachiaudi, M. Laville, J. Pousin, M. Armstrong, M. Lagarde
- BiologyJournal of lipid research
- 1 October 1999
It is concluded that the lipid form of ingested DHA affects markedly its kinetics and partly its metabolic fate, which differs from what was previously been observed after intake of triglycerides labeled with [(13)C]DHA.
Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells.
It is found that plasma albumin carried another source of 22:6, lyso-phosphatidylcholines (lyso-PC), in which [13C]22:6 accumulated while the nonesterified [ 13C]23:6 reached its minimal plasma concentrations.
Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton.
The hypothesis that PLD participates in myogenesis through PA- and PIP2-dependent actin fiber formation is supported, as it is shown thatPLD1 is involved in this process.