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Leukotriene A4

Known as: LTA4, Leukotriene A-4, Leukotriene A4 [Chemical/Ingredient] 
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

11,12-leukotriene A414,15-dehydroleukotriene A414,15-leukotriene A45,6-methanoleukotriene A4
In BloodProcess of secretionagonistsanalogs & derivatives

Broader (1)

Leukotriene A

Papers overview

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Highly Cited
1997
Highly Cited
1997
Production of Leukotriene C4 in Different Human Tissues Is Attributable to Distinct Membrane Bound Biosynthetic Enzymes*
Microsomal glutathione S-transferase-II (GST-II) has recently been discovered and characterized as a member of the 5-lipoxygenase… 
Highly Cited
1992
Highly Cited
1992
Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.
The metal-binding motif in the sequence of leukotriene A4 (LTA4) (EC 3.3.2.6), a bifunctional zinc metalloenzyme, contains a… 
Highly Cited
1991
Highly Cited
1991
Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.
Highly Cited
1991
Highly Cited
1991
Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction.
Highly Cited
1989
Highly Cited
1989
Purification of hepoxilin epoxide hydrolase from rat liver.
Highly Cited
1988
Highly Cited
1988
Novel transcellular interaction: conversion of granulocyte-derived leukotriene A4 to cysteinyl-containing leukotrienes by human platelets.
Human platelets dose-dependently converted exogenous leukotriene A4 to leukotriene C4 and efficiently metabolized this compound… 
Highly Cited
1987
Highly Cited
1987
Leukotrienes stimulate initiation of DNA synthesis in cultured arterial smooth muscle cells.
The effects of leukotrienes on initiation of DNA synthesis in growth-arrested arterial smooth muscle cells cultivated in a… 
Highly Cited
1983
Highly Cited
1983
Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes.
Leukocyte preparations convert the hydroperoxy icosatetraenoic acids 5(S)-HPETE and 15(S)-HPETE to the unstable leukotriene… 
Highly Cited
1982
Highly Cited
1982
Leukotriene‐induced neutrophil aggregation in vitro
Highly Cited
1982
Highly Cited
1982
Studies on the mechanism of formation of the 5S, 12S-dihydroxy-6,8,10,14(E,Z,E,Z)-icosatetraenoic acid in leukocytes.
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