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Leukotriene A4

Known as: LTA4, Leukotriene A-4, Leukotriene A4 [Chemical/Ingredient] 
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate… Expand
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

11,12-leukotriene A414,15-dehydroleukotriene A414,15-leukotriene A45,6-methanoleukotriene A4
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In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (1)

Leukotriene A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
MMP generated matrikines.
Matrikines originate from the fragmentation of extracellular matrix proteins and regulate cellular activities by interacting with… Expand
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Highly Cited
2013
Highly Cited
2013
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-aged women, and its etiology is poorly… Expand
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Review
2011
Review
2011
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
4. Biosynthesis of Leukotrienes 5869 4.1. Discovery of the Leukotriene Pathway and a Common Unstable Intermediate 5869 4.2… Expand
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Highly Cited
2009
Highly Cited
2009
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential… Expand
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… Expand
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Highly Cited
2006
Highly Cited
2006
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be… Expand
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Review
1995
Review
1995
Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases.
The eicosanoids are a family of oxygenated arachidonic acid derivatives that potently mediate diverse physiological and… Expand
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Highly Cited
1990
Highly Cited
1990
Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.
Human neutrophils from peripheral blood may physically interact with platelets in several settings including hemostasis… Expand
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Highly Cited
1988
Highly Cited
1988
Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.
Transformation of leukotriene (LT) A4 into leukotriene C4 has been found to be carried out by human platelets in a rather… Expand
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Review
1987
Review
1987
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… Expand
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