FAQ

Leukotriene A4

Known as: LTA4, Leukotriene A-4, Leukotriene A4 [Chemical/Ingredient] 
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
0204019802018

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11 relations

Narrower (1)

14,15-dehydroleukotriene A4
In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (1)

Leukotriene A

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Leukotriene A4
physiological aspects
In Blood
chemical synthesis
standards characteristics
Process of secretion

Papers overview

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Highly Cited
2006
Highly Cited
2006
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be… (More)
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2006
2006
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.
Regulation of 5-lipoxygenase (5LO) activity is a key determinant for the biosynthesis of proinflammatory leukotrienes. Coactosin… (More)
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Highly Cited
2001
Highly Cited
2001
Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation
Leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc enzyme that catalyzes the biosynthesis of LTB4, a… (More)
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2001
2001
Leukotriene A4 Hydrolase in Human Leukocytes
Leukotriene A4 hydrolase, a soluble enzyme catalyzing hydrolysis of the allylic epoxide leukotriene A4 to the dihydroxy acid… (More)
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1996
1996
Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes.
The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid, leukotriene A4, is known to be released from… (More)
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Highly Cited
1994
Highly Cited
1994
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.
Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced… (More)
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Highly Cited
1988
Highly Cited
1988
Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.
Transformation of leukotriene (LT) A4 into leukotriene C4 has been found to be carried out by human platelets in a rather… (More)
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1986
1986
Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.
The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for… (More)
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Highly Cited
1986
Highly Cited
1986
Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.
Leukotriene (LT) synthesis and metabolism were studied in porcine aortic endothelial cells. Leukotrienes were identified by… (More)
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1982
1982
Albumin stabilizes leukotriene A4.
Chemical analysis of intact leukotriene A4 showed that vertebrate albumins prolonged its aqueous half-life. At pH 7.4… (More)
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