Leukotriene A4

Known as: LTA4, Leukotriene A-4, Leukotriene A4 [Chemical/Ingredient] 
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
0204019802018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be… (More)
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2006
2006
Regulation of 5-lipoxygenase (5LO) activity is a key determinant for the biosynthesis of proinflammatory leukotrienes. Coactosin… (More)
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Highly Cited
2001
Highly Cited
2001
Leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc enzyme that catalyzes the biosynthesis of LTB4, a… (More)
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2001
2001
Leukotriene A4 hydrolase, a soluble enzyme catalyzing hydrolysis of the allylic epoxide leukotriene A4 to the dihydroxy acid… (More)
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1996
1996
The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid, leukotriene A4, is known to be released from… (More)
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Highly Cited
1994
Highly Cited
1994
Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced… (More)
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Highly Cited
1988
Highly Cited
1988
Transformation of leukotriene (LT) A4 into leukotriene C4 has been found to be carried out by human platelets in a rather… (More)
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1986
1986
The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for… (More)
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Highly Cited
1986
Highly Cited
1986
Leukotriene (LT) synthesis and metabolism were studied in porcine aortic endothelial cells. Leukotrienes were identified by… (More)
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1982
1982
Chemical analysis of intact leukotriene A4 showed that vertebrate albumins prolonged its aqueous half-life. At pH 7.4… (More)
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