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Leukotriene A4
Known as:
LTA4
, Leukotriene A-4
, Leukotriene A4 [Chemical/Ingredient]
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(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate…
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National Institutes of Health
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Related topics
Related topics
15 relations
Narrower (5)
11,12-leukotriene A4
14,15-dehydroleukotriene A4
14,15-leukotriene A4
5,6-methanoleukotriene A4
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In Blood
Process of secretion
agonists
analogs & derivatives
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Broader (1)
Leukotriene A
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
J. Haeggström
,
C. Funk
Chemical Reviews
2011
Corpus ID: 42034548
4. Biosynthesis of Leukotrienes 5869 4.1. Discovery of the Leukotriene Pathway and a Common Unstable Intermediate 5869 4.2…
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Highly Cited
2009
Highly Cited
2009
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
C. Jeong
,
A. Bode
,
+7 authors
Z. Dong
Cancer Research
2009
Corpus ID: 974631
[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential…
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
R. Murphy
,
M. Gijón
Biochemical Journal
2007
Corpus ID: 22896357
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO…
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Highly Cited
2006
Highly Cited
2006
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
A. Helgadóttir
,
A. Manolescu
,
+28 authors
K. Stefánsson
Nature Genetics
2006
Corpus ID: 31245403
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be…
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Review
2001
Review
2001
Cooperation of Liver Cells in Health and Disease
Z. Kmieć
Advances in Anatomy, Embryology and Cell Biology
2001
Corpus ID: 7714118
The liver lobule is formed by parenchymal cells, i.e., hepatocytes and nonparenchymal cells. In contrast to hepatocytes that…
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Review
1994
Review
1994
The Role of Leukotrienes in Inflammation
W. Henderson
Annals of Internal Medicine
1994
Corpus ID: 34810055
Leukotrienes, together with prostaglandins, thromboxanes, and lipoxins, are the major constituents of a group of biologically…
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Highly Cited
1994
Highly Cited
1994
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.
B. Lam
,
J. Penrose
,
G. Freeman
,
K. Austen
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 24957029
Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced…
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Highly Cited
1990
Highly Cited
1990
Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.
C. Serhan
,
K. Sheppard
Journal of Clinical Investigation
1990
Corpus ID: 30016520
Human neutrophils from peripheral blood may physically interact with platelets in several settings including hemostasis…
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Review
1987
Review
1987
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
B. Samuelsson
,
S. Dahlén
,
J. Lindgren
,
C. Rouzer
,
C. Serhan
Science
1987
Corpus ID: 43753152
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium…
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Highly Cited
1983
Highly Cited
1983
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.
B. Samuelsson
Science
1983
Corpus ID: 19766014
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