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Leukotriene A4

Known as: LTA4, Leukotriene A-4, Leukotriene A4 [Chemical/Ingredient] 
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

11,12-leukotriene A414,15-dehydroleukotriene A414,15-leukotriene A45,6-methanoleukotriene A4
In BloodProcess of secretionagonistsanalogs & derivatives

Broader (1)

Leukotriene A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
4. Biosynthesis of Leukotrienes 5869 4.1. Discovery of the Leukotriene Pathway and a Common Unstable Intermediate 5869 4.2… 
Highly Cited
2009
Highly Cited
2009
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential… 
Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… 
Highly Cited
2006
Highly Cited
2006
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be… 
Review
2001
Review
2001
Cooperation of Liver Cells in Health and Disease
  • Z. Kmieć
  • Advances in Anatomy, Embryology and Cell Biology
  • 2001
  • Corpus ID: 7714118
The liver lobule is formed by parenchymal cells, i.e., hepatocytes and nonparenchymal cells. In contrast to hepatocytes that… 
Review
1994
Review
1994
The Role of Leukotrienes in Inflammation
  • W. Henderson
  • Annals of Internal Medicine
  • 1994
  • Corpus ID: 34810055
Leukotrienes, together with prostaglandins, thromboxanes, and lipoxins, are the major constituents of a group of biologically… 
Highly Cited
1994
Highly Cited
1994
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.
Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced… 
Highly Cited
1990
Highly Cited
1990
Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.
Human neutrophils from peripheral blood may physically interact with platelets in several settings including hemostasis… 
Review
1987
Review
1987
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… 
Highly Cited
1983
Highly Cited
1983
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.
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