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Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners*
TLDR
It is confirmed that a specific phospholipase D is responsible for the generation of N-acylethanolamines including anandamide, strongly suggesting the physiological importance of lipid molecules of this class.
Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase*
TLDR
Comb complementary DNA cloning and functional expression of the enzyme termed “N-acylethanolamine-hydrolyzing acid amidase (NAAA)” from human, rat, and mouse demonstrated that NAAA is a novel N-acyleddylamine-Hydrolyzed enzyme that shows structural and functional similarity to acid ceramidase.
Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance*
TLDR
The new enzyme referred to as N-palmitoylethanolamine hydrolase was clearly distinguishable from anandamide amidohydrolase and was the most active at pH 5 and was activated 7-fold by Triton X-100.
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
TLDR
The results suggest that anandamide and 2‐arachidonoylglycerol can be inactivated by the same enzyme.
Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.
TLDR
A potential role of both NF-IL6 and NF kappa B in the induction of cyclooxygenase-2 by TNF alpha is suggested, as examined by the luciferase assay.
The fatty acid amide hydrolase (FAAH).
TLDR
The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid, and a large number of inhibitors have been synthesized and tested since 1994 and these are reviewed in terms of reversibility, potency, and specificity.
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.
TLDR
Porcine brain has at least two enzymes capable of hydrolyzing 2-AG, and both the cytosolic and particulate enzymes were irreversibly and time-dependently inhibited by methyl arachidonyl fluorophosphonate with IC50 values as low as 2-3 nM.
Transcriptional Roles of Nuclear Factor B and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor -Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells (*)
TLDR
Data suggested a potential role of both NF-IL6 and NFκB in the induction of cyclooxygenase-2 by TNFα, as judged by the inhibitory effect of NS398, Western blotting, and Northern blotting.
The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)
TLDR
Cloned cDNA of N‐acylethanolamine‐hydrolyzing acid amidase (NAAA), another enzyme catalyzing the same reaction, from human, rat, and mouse indicates a novel lysosomal hydrolase, which is structurally and functionally similar to acid ceramidase.
Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide (*)
TLDR
On the basis of cochromatographies, pH dependence, heat inactivation, and effects of inhibitors, it was suggested that the anandamide amidohydrolase and synthase activities were attributable to a single enzyme protein.
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