Skip to search formSkip to main contentSkip to account menu

Lead Compound

Known as: Lead compounds 
An inorganic or organic substance that contains the metallic element lead either in its positive-2 or 4 valence state. Lead compounds have a wide… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse
Background: The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory… 
Highly Cited
2009
Highly Cited
2009
Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data.
Highly Cited
2009
Highly Cited
2009
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
Highly Cited
2008
Highly Cited
2008
The Sustainability of Ethanol Production from Sugarcane
Highly Cited
2005
Highly Cited
2005
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.
The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering… 
Highly Cited
2002
Highly Cited
2002
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.
The generation and/or optimization of lead compounds by combinatorial methods has become widely accepted in medicinal chemistry… 
Review
2000
Review
2000
Lead as a carcinogen: experimental evidence and mechanisms of action.
Recent epidemiological and experimental work confirms that inorganic lead compounds are associated with increased risks of… 
Highly Cited
1999
Highly Cited
1999
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
Highly Cited
1996
Highly Cited
1996
Synthesis and Applications of Small Molecule Libraries.
One of the initial steps in the development of therapeutic agents is the identification of lead compounds that bind to the… 
Highly Cited
1996
Highly Cited
1996
Dimethyl carbonate for environmentally benign reactions
Abstract 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)