Biochemical Studies on the Toxicity of Tetraethyl Lead and Other Organo-Lead Compounds

@article{Cremer1959BiochemicalSO,
  title={Biochemical Studies on the Toxicity of Tetraethyl Lead and Other Organo-Lead Compounds},
  author={Jill E. Cremer},
  journal={British Journal of Industrial Medicine},
  year={1959},
  volume={16},
  pages={191 - 199}
}
  • J. E. Cremer
  • Published 1 July 1959
  • Chemistry, Biology
  • British Journal of Industrial Medicine
The actions of purified tetra-, tri-, and di-ethyl lead on rats and rat brain slices and brain brei have been examined. A method based on a reaction with dithizone and capable of estimating tri- and di-ethyl tin in rat tissues has been developed. After injection into rats tetraethyl lead is converted into triethyl lead and this is responsible for the toxic effects. Diethyl lead is much less toxic and the effects are different. The utilization of lactate and the oxidation of glucose by brain… 

Tetraethyl Lead Toxicity in Rats

It was found that brain slices prepared from rats injected with tetraethyl lead or tin were able to metabolize glucose at a normal rate but that there was some impairment in their ability to utilize glutamate or glycine.

THE ACTION OF TRIETHYL TIN, TRIETHYL LEAD, ETHYL MERCURY AND OTHER INHIBITORS ON THE METABOLISM OF BRAIN AND KIDNEY SLICES IN VITRO USING SUBSTRATES LABELLED WITH 14C

The present work was undertaken using 14C-labelled substrates in an attempt to throw further light on (a) the selective action of triethyl tin and triethyl lead on brain slices in vitro, and (b) the relationship between biochemical changes and signs of intoxication by these two compounds.

Distribution and Excretion of Triethyllead in Rats

  • W. Bolanowska
  • Chemistry, Medicine
    British journal of industrial medicine
  • 1968
The distribution and excretion of triethyllead and inorganic lead in rats have been studied after the intravenous administration of tetraethyllead, using a new method for separating triethyllead.

Microdetermination and dynamic aspects of in vivo alkyl lead compounds. II. Studies on the dynamic aspects of alkyl lead compounds in vivo.

  • K. Hayakawa
  • Chemistry, Medicine
    Nihon eiseigaku zasshi. Japanese journal of hygiene
  • 1972
The author analyzed the trialkyl lead from the urine of workers on the factory where lead added gasoline was used, and found it even in case of no clinical symptoms, and this method facilitates factory health administration services.

Excretion of Triethyllead in Rats

The distribution and excretion of triethyllead and inorganic lead in rats have been studied after the intravenous administration of tetraethyllead, using a new method for separating triethyllead.

On the toxic effects of tetraethyl lead and its derivatives on the chrysophyte Poterioochromonas malhamensis. III. Chemical analyses

The photolytic decomposition of tetraethyl lead (TEL) into the derivatives triethyl lead (TriEL), diethyl lead (DiEL), and into inorganic lead in an aqueous environment was examined by using a

Tetramethyl lead absorption: a report of human exposure to a high level of tetramethyl lead.

  • J. Gething
  • Medicine
    British journal of industrial medicine
  • 1975
This report shows that the urinary lead levels give a better guide to the degree of absorption of tetramethyl lead compared with the blood lead or urinary ALA levels, and illustrates that tetram methyl lead is less toxic to man than tetraethyl lead.
...

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