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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
- A. Quintás-Cardama, K. Vaddi, S. Verstovsek
- Biology, MedicineBlood
- 15 April 2010
TLDR
Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
- J. Fridman, P. Scherle, K. Vaddi
- Biology, MedicineThe Journal of Immunology
- 1 May 2010
TLDR
Treatment methods for the remediation of nitroaromatic explosives.
- J. Rodgers, N. Bunce
- ChemistryWater research
- 1 June 2001
Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
- A. Shilling, Frank M Nedza, S. Yeleswaram
- Chemistry, BiologyDrug Metabolism and Disposition
- 1 November 2010
TLDR
Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation.
- J. Fridman, P. Scherle, K. Vaddi
- BiologyThe Journal of investigative dermatology
- 1 September 2011
JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the pathogenesis of inflammatory skin diseases…
Downmodulation of key inflammatory cell markers with a topical Janus kinase 1/2 inhibitor
- N. Punwani, T. Burn, A. Gottlieb
- BiologyThe British journal of dermatology
- 1 October 2015
INCB018424 is a novel, potent Janus kinase (JAK)1/JAK2 inhibitor that blocks signal transduction of multiple proinflammatory cytokines.
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
- J. W. Corbett, S. Ko, S. Erickson-Viitanen
- Chemistry, BiologyJournal of medicinal chemistry
- 18 May 2000
TLDR
Electrochemical oxidation of chlorinated phenols
- J. Rodgers, W. Jȩdral, N. Bunce
- Chemistry, Materials Science
- 24 March 1999
Electrochemical oxidation has been proposed as a remediation method for chlorinated phenols but is hampered by anode fouling. In this work we explore the mechanism of anode fouling by chlorinated…
Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1
- J. W. Corbett, S. Ko, S. Erickson-Viitanen
- Chemistry, BiologyAntimicrobial Agents and Chemotherapy
- 1 December 1999
ABSTRACT A research program targeted toward the identification of expanded-spectrum nonnucleoside reverse transcriptase inhibitors which possess increased potency toward K103N-containing mutant human…
Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction.
- Q. Lin, David J. Meloni, Jiacheng Zhou
- Chemistry, BiologyOrganic letters
- 27 March 2009
An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3-cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the…
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