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- Publications
- Influence
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
- E. Sudbeck, X. Liu, +4 authors F. Uckun
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 June 1999
A novel homology model of the kinase domain of Janus kinase (JAK) 3 was used for the structure-based design of dimethoxyquinazoline compounds with potent and specific inhibitory activity against… Expand
Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton′s Tyrosine Kinase (BTK), LFM-A13 [α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl)Propenamide]*
- S. Mahajan, S. Ghosh, +4 authors F. Uckun
- Medicine, Biology
- The Journal of Biological Chemistry
- 2 April 1999
In a systematic effort to design potent inhibitors of the anti-apoptotic tyrosine kinase BTK (Bruton′s tyrosine kinase) as anti-leukemic agents with apoptosis-promoting and chemosensitizing… Expand
Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting
- S. Mahajan, S. Ghosh, +4 authors F. Uckun
- 1999
In a systematic effort to design potent inhibitors of the anti-apoptotic tyrosine kinase BTK (Bruton*s tyrosine kinase) as anti-leukemic agents with apoptosis-promoting and chemosensitizing… Expand
- 26
- 3
Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes.
- Y. Dong, R. Narla, E. Sudbeck, F. Uckun
- Chemistry, Medicine
- Journal of inorganic biochemistry
- 31 March 2000
In a systematic effort to identify and develop effective anticancer agents, four oxovanadium(IV) complexes with 1,10-phenanthroline (Phen) or 4,7-dimethyl-1,10-phenanthroline (Me2-Phen) as ligand(s)… Expand
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
- C. Mao, E. Sudbeck, T. Venkatachalam, F. Uckun
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 7 June 1999
The novel thiourea compound N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thi ourea (HI-236) targeting the non-nucleoside inhibitor (NNI) binding pocket of HIV-1 reverse transcriptase (RT)… Expand
Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase
- E. Sudbeck, C. Mao, R. Vig, T. Venkatachalam, L. Tuel-ahlgren, F. Uckun
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 December 1998
ABSTRACT Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase… Expand
Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase
- R. Vig, Chen Mao, T. Venkatachalam, L. Tuel-ahlgren, E. Sudbeck, F. M. Uckun
- Chemistry
- 1 October 1998
Abstract A series of novel phenethylthiazolylthiourea (PETT) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of HIV reverse transcriptase (RT) have been designed based on the… Expand
Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.
- C. Mao, E. Sudbeck, T. Venkatachalam, F. Uckun
- Medicine, Chemistry
- Biochemical pharmacology
- 1 November 2000
The generation of anti-HIV agents using structure-based drug design methods has yielded a number of promising non-nucleoside inhibitors (NNIs) of HIV reverse transcriptase (RT). Recent successes in… Expand
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.
- V. Atigadda, W. Brouillette, +12 authors G. Laver
- Chemistry, Medicine
- Journal of medicinal chemistry
- 4 June 1999
On the basis of the lead compound 4-(N-acetylamino)-3-guanidinobenzoic acid (BANA 113), which inhibits influenza A sialidase with a Ki of 2.5 microM, several novel aromatic inhibitors of influenza… Expand
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
- F. Uckun, C. Mao, +5 authors R. Narla
- Medicine, Chemistry
- Current opinion in investigational drugs
- 1 October 2000
Agents that either promote or inhibit tubulin polymerization exhibit anticancer activity by disrupting normal mitotic spindle assembly and cell division as well as inducing apoptosis. Recently… Expand