T. Venkatachalam

Publications197
h-index28
Citations2,464
Highly Influential Citations34
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Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.
TLDR
The findings indicate that the highly conserved active site residues responsible for the depurination of rRNA by PAP or RTA are not sufficient for the recognition and depurinations of viral RNA.
Quantitative functional brain imaging with positron emission tomography
TLDR
One of recommendation of the book that you need to read, quantitative functional brain imaging with positron emission tomography, written by an experienced author is shown.
Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells.
TLDR
The results indicate that the EGF-R-associated PTK complexes have vital antiapoptotic functions in human breast cancer cells and may therefore be used as therapeutic targets.
Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.
TLDR
Experimental evidence is provided that the stereochemistry as well as regiochemistry of NNRTI can profoundly affect their anti-HIV activity.
Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein.
TLDR
To the knowledge, these findings provide the first evidence that PAP can deguanylate both ribosomal and viral RNA.
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
TLDR
HI-236 was highly effective against the multidrug-resistant HIV-1 strain RT-MDR with multiple mutations involving the RT residues 74V, 41L, 106A, and 215Y and twice as effective as the recently reported lead compound N-[2-fluorophenethyl]-N'-[2-(5-bromopyridyl)]-thiourea.
X‐ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA
TLDR
Unprecedented experimental evidence is presented that PAP can release not only adenine but guanine as well from Escherichia coli rRNA, albeit at a rate 20 times slower than forAdenine.
Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase
ABSTRACT Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase…
Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus.
TLDR
Sperm motion kinematics using computer-assisted sperm motion analysis combined with confocal laser scanning microscopy, high-resolution low-voltage scanning, and transmission electron microscopy demonstrated that both WHI-05 andWHI-07 cause a complete and irreversible loss of sperm motility in a concentration- and time-dependent fashion without concomitantly affecting the sperm acrosomal membrane integrity.
Novel Thiourea Compounds as Dual-Function Microbicides
TLDR
It is concluded that as potent anti-HIV agents with SIA and reduced cytotoxicity when compared with N-9, the phenyl-substituted and cyclohexenyl-based thiourea derivatives show unique clinical potential to become the active ingredients of a vaginal contraceptive for women who are at high risk for acquiring HIV by heterosexual vaginal transmission.
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