FAQ

Lactase-Phlorizin Hydrolase

Known as: Glycosylceramidase, Hydrolase, Lactase-Phlorizin, Lactase-Glycosylceramidase 
The multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
051019522016

Related topics

Related topics

11 relations
GlycosylceramidaseIn BloodLCT geneLactose Intolerance
(More)

Narrower (1)

pro-lactase-phlorizin hydrolase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Lactase-Phlorizin Hydrolase
physiological aspects
In Blood
chemical synthesis
Lactose Intolerance
standards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
Lactase-phlorizin hydrolase (LPH), a marker of intestinal differentiation, is expressed in absorptive enterocytes on small… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia.
BACKGROUND AND AIMS The mechanism of the developmental downregulation of the lactase-phlorizin hydrolase (LPH) gene underlying… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.
Lactase phlorizin hydrolase (LPH; EC 3.2.1.62) is a membrane-bound, family 1 beta-glycosidase found on the brush border of the… (More)
Is this relevant?
2000
2000
Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.
Lactase-phlorizin hydrolase is a brush-border enzyme which is specifically expressed in the small intestine where it hydrolyses… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1998
1998
The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription.
The lactase-phlorizin hydrolase (LPH) gene is expressed specifically in the enterocytes of the small intestine. LPH levels are… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2.
Lactase-phlorizin hydrolase is exclusively expressed in the small intestine and is often used as a marker for the differentiation… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
1997
1997
Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs.
We have examined the effect of protein malnutrition on brush border (BB) lactase phlorizin hydrolase (LPH) synthesis in young… (More)
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.
We report the primary structures of human and rabbit brush border membrane beta-glycosidase complexes (pre-pro-lactase-phlorizin… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells
A panel of monoclonal antibodies was produced against purified microvillus membranes of human small intestinal enterocytes. By… (More)
  • table I
  • figure 1
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
1982
1982
Further characterization of intestinal lactase/phlorizin hydrolase.
Pig intestinal lactase/phlorizin hydrolase (EC 3.2.1.23/62) was purified in its amphiphilic form by immunoadsorbent… (More)
Is this relevant?