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Lactase-Phlorizin Hydrolase

Known as: Glycosylceramidase, Hydrolase, Lactase-Phlorizin, Lactase-Glycosylceramidase 
The multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N… Expand
National Institutes of Health

Related topics

Related topics

10 relations
GlycosylceramidaseIn BloodLCT geneLactose Intolerance
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.
Two hypotheses on absorption mechanisms of flavonoid glucosides across the small intestine have been proposed: active uptake of… Expand
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Highly Cited
2003
Highly Cited
2003
Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element.
Lactase persistence is a heritable, autosomal dominant, condition that results in a sustained ability to digest the milk sugar… Expand
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Review
2003
Review
2003
Genetics of lactase persistence and lactose intolerance.
The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in… Expand
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Highly Cited
2003
Highly Cited
2003
Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia.
BACKGROUND AND AIMS The mechanism of the developmental downregulation of the lactase-phlorizin hydrolase (LPH) gene underlying… Expand
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Highly Cited
2000
Highly Cited
2000
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.
Lactase phlorizin hydrolase (LPH; EC 3.2.1.62) is a membrane-bound, family 1 beta-glycosidase found on the brush border of the… Expand
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Highly Cited
2000
Highly Cited
2000
Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.
Lactase-phlorizin hydrolase is a brush-border enzyme which is specifically expressed in the small intestine where it hydrolyses… Expand
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Highly Cited
1997
Highly Cited
1997
Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2.
Lactase-phlorizin hydrolase is exclusively expressed in the small intestine and is often used as a marker for the differentiation… Expand
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Review
1991
Review
1991
Lactose intolerance and the genetic regulation of intestinal lactase-phlorizin hydrolase.
Lactase-phlorizin hydrolase, which hydrolyzes lactose, the major carbohydrate in milk, plays a critical role in the nutrition of… Expand
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Highly Cited
1988
Highly Cited
1988
Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.
We report the primary structures of human and rabbit brush border membrane beta-glycosidase complexes (pre-pro-lactase-phlorizin… Expand
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Highly Cited
1985
Highly Cited
1985
Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells
A panel of monoclonal antibodies was produced against purified microvillus membranes of human small intestinal enterocytes. By… Expand
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