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Lactase-Phlorizin Hydrolase

Known as: Glycosylceramidase, Hydrolase, Lactase-Phlorizin, Lactase-Glycosylceramidase 
The multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N… 
National Institutes of Health

Related topics

Related topics

10 relations
GlycosylceramidaseIn BloodLCT geneLactose Intolerance

Papers overview

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Highly Cited
2004
Highly Cited
2004
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
Lactase-phlorizin hydrolase (LPH), a marker of intestinal differentiation, is expressed in absorptive enterocytes on small… 
Highly Cited
2000
Highly Cited
2000
Differential mechanism-based labeling and unequivocal activity assignment of the two active sites of intestinal lactase/phlorizin hydrolase.
Milk lactose is hydrolysed to galactose and glucose in the small intestine of mammals by the lactase/phlorizin hydrolase complex… 
Highly Cited
2000
Highly Cited
2000
Investigation of Three Doses of Oral Insulin-like Growth Factor-I on Jejunal Lactase Phlorizin Hydrolase Activity and Gene Expression and Enterocyte Proliferation and Migration in Piglets
In a previous study, oral IGF-I at 65 nM increased lactase phlorizin hydrolase (LPH) activity and villus height in piglets… 
2000
2000
Additional N-Glycosylation and Its Impact on the Folding of Intestinal Lactase-phlorizin Hydrolase*
Lactase-phlorizin hydrolase (LPH) is a membrane bound intestinal hydrolase, with an extracellular domain comprising 4 homologous… 
1999
1999
Hierarchy of Sorting Signals in Chimeras of Intestinal Lactase-Phlorizin Hydrolase and the Influenza Virus Hemagglutinin*
Lactase-phlorizin hydrolase (LPH) is an apical protein in intestinal cells. The location of sorting signals in LPH was… 
1998
1998
The HOXC11 Homeodomain Protein Interacts with the Lactase-Phlorizin Hydrolase Promoter and Stimulates HNF1α-dependent Transcription*
The lactase-phlorizin hydrolase (LPH) gene is expressed specifically in the enterocytes of the small intestine. LPH levels are… 
Highly Cited
1997
Highly Cited
1997
Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2.
Lactase-phlorizin hydrolase is exclusively expressed in the small intestine and is often used as a marker for the differentiation… 
Highly Cited
1993
Highly Cited
1993
Regional localization of the lactase‐phlorizin hydrolase gene, LCT, to chromosome 2q21
The gene LCT which codes for the intestinal disaccharidase lactase‐phlorizin hydrolase has previously been mapped, using somatic… 
Highly Cited
1992
Highly Cited
1992
A novel intestinal trans-factor (NF-LPH1) interacts with the lactase-phlorizin hydrolase promoter and co-varies with the enzymatic activity.
The promoter of the pig lactase-phlorizin hydrolase was cloned and showed to be functional in the human intestinal cell line… 
1968
1968
Is phloretin the sugar transport inhibitor in intestine?
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