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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
TLDR
Evidence is provided for a new role of Transglutaminase in the common, HLA-DQ2 (and DQ8) associated celiac disease and it is demonstrated that TGase mediates its effect through an ordered and specific deamidation of gliadins.
Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site
TLDR
It is shown that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity, and the view that the catalytic site and the TGEV receptor site are located in different domains.
Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2.
TLDR
It was shown that the factor C dx-2 (a homoeodomain-protein related to caudal) binds to a TTTAC sequence in the CE-LPH1, and it was demonstrated that Cdx-2 is able to activate reporter gene transcription by binding to CE- LPH1.
Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.
TLDR
It is shown that the presence of both factors leads to a much higher level of transcription than the sum of the activation by either factor alone, the first demonstration of a functional interaction between two transcription factors involved in the activation of a number of intestine-specific genes.
Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C
TLDR
Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN), which may trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry.
Purification and characterisation of amphiphilic lactase/phlorizin hydrolase from human small intestine.
TLDR
It is suggested that the human lactase/phlorizin hydrolase is composed of two monomers each with a molecular weight of 160000, and the possibility of a high molecular weight, one polypeptide chain is discussed.
Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C.
TLDR
Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN), may trigger conformational changes in the viral spike protein at 37 degrees C that facilitate virus entry.
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