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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
The action of tissue Transglutaminase1 (TGase) on specific protein-bound glutamine residues plays a critical role in numerous biological processes2–5. Here we provide evidence for a new role of thisExpand
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Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.
The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substituteExpand
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Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA
The complete primary structure (967 amino acids) of an intestinal human aminopeptidase N (EC 3.4.11.2) was deduced from the sequence of a cDNA clone. Aminopeptidase N is anchored to the microvillarExpand
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Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2.
Lactase-phlorizin hydrolase is exclusively expressed in the small intestine and is often used as a marker for the differentiation of enterocytes. The cis-element CE-LPH1 found in theExpand
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Transcriptional regulation of pig lactase-phlorizin hydrolase: involvement of HNF-1 and FREACs.
BACKGROUND & AIMS One-kilobase sequence of the upstream fragment of the pig lactase-phlorizin hydrolase gene has been shown to control small intestinal-specific expression and postweaning decline ofExpand
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Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.
Lactase-phlorizin hydrolase is a brush-border enzyme which is specifically expressed in the small intestine where it hydrolyses lactose, the main carbohydrate found in milk. We have previouslyExpand
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Purification and characterisation of amphiphilic lactase/phlorizin hydrolase from human small intestine.
Human intestinal lactase/phlorizin hydrolase (EC 3.2.1.23/62) was purified in its amphiphilic form by immunoadsorbent chromatography. The purification factor was approximately 600 and the recoveryExpand
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Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C
ABSTRACT Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralizedExpand
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The Coronavirus Transmissible Gastroenteritis Virus Causes Infection after Receptor-Mediated Endocytosis and Acid-Dependent Fusion with an Intracellular Compartment
ABSTRACT Aminopeptidase N is a species-specific receptor for transmissible gastroenteritis virus (TGEV), which infects piglets, and for the 229E virus, which infects humans. It is not known whetherExpand
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