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LY 389795

Known as: LY-389795, LY389795 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Amino AcidsBridged Bicyclo Compounds, Heterocyclic

Papers overview

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Highly Cited
2007
Highly Cited
2007
Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally…
(-)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate (LY389795, (-)-3) is a highly potent and selective agonist of… Expand
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Highly Cited
2005
Highly Cited
2005
Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
Group II (mGluR2/3) metabotropic glutamate receptors have been implicated in the mechanisms of persistent pain states. In the… Expand
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Highly Cited
2003
Highly Cited
2003
Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models
Glutamatergic ionotropic and metabotropic receptor modulators have been shown to produce anticonvulsant activity in a number of… Expand
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Highly Cited
2002
Highly Cited
2002
Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats
The involvement of Group II metabotropic receptors in acute and persistent pain states was evaluated in several in vivo models of… Expand
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Highly Cited
2001
Highly Cited
2001
Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6…
The selective group II metabotropic glutamate receptor (mGlu(2/3)) agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6… Expand
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Highly Cited
1999
Highly Cited
1999
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two…
As part of our ongoing research program aimed at the identification of highly potent, selective, and systemically active agonists… Expand
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Highly Cited
1999
Highly Cited
1999
Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors
ABSTRACT: The role of group I metabotropic glutamate (mGlu) receptors in neurodegeneration is controversial because of the… Expand
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1999
1999
Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795.
In rat cortical neuronal cultures, metabotropic glutamate (mGlu) receptor agonists: LY354740 (+)-2-aminobicyclo[3.1.0]hexane-2… Expand
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