LBM415
National Institutes of Health
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Peptide deformylase (PDF) inhibitors represent a potential new class of antibiotics targeting a large number of bacterial species…
ABSTRACT LBM415 is an antibacterial agent belonging to the peptide deformylase inhibitor class of compounds. It has previously…
ABSTRACT Previous genetic analysis of Haemophilus influenzae revealed two mechanisms associated with decreased susceptibility to…
OBJECTIVES
To evaluate the spectrum of activity and potency of LBM415, the first of the peptide deformylase inhibitor (PDFI…
ABSTRACT When tested against 254 Haemophilus influenzae strains, LBM415, a peptide deformylase inhibitor, gave MIC50 and MIC90…
ABSTRACT LBM415 is a peptide deformylase inhibitor active against gram-positive bacterial species and some gram-negative species…
ABSTRACT LBM415 (NVP PDF-713) is the first member of the peptide deformylase (PDF) inhibitor class being developed for clinical…
Fluconazole MICs obtained with the modified BMD tests and Etest read at 24 and 48 h were compared with the reference BMD MICs…
ABSTRACT The MICs of LBM415, a new peptide diformylase inhibitor, were ≤0.06 to 4.0 μg/ml for 258 isolates of Staphylococcus…
ABSTRACT The MICs of LBM415, a new peptide diformylase inhibitor, were evaluated and ranged from 0.03 to 4.0 μg/ml for 300…