LBM415
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
ABSTRACT LBM415 is an antibacterial agent belonging to the peptide deformylase inhibitor class of compounds. It has previously…
ABSTRACT The intrinsic resistance of P. aeruginosa PAO1 to the peptide deformylase inhibitor (PDF-I) LBM415 was mediated by the…
ABSTRACT Previous genetic analysis of Haemophilus influenzae revealed two mechanisms associated with decreased susceptibility to…
OBJECTIVES
To evaluate the spectrum of activity and potency of LBM415, the first of the peptide deformylase inhibitor (PDFI…
ABSTRACT Haemophilus influenzae isolates vary widely in their susceptibilities to the peptide deformylase inhibitor LBM415 (MIC…
ABSTRACT LBM415 (NVP PDF-713) is the first member of the peptide deformylase (PDF) inhibitor class being developed for clinical…
ABSTRACT Mycoplasma pneumoniae is a major cause of community-acquired pneumonia. We evaluated the efficacy of LBM415, a novel…
Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth but is not required by mammalian…
ABSTRACT The MICs of LBM415, a new peptide diformylase inhibitor, were ≤0.06 to 4.0 μg/ml for 258 isolates of Staphylococcus…
ABSTRACT The MICs of LBM415, a new peptide diformylase inhibitor, were evaluated and ranged from 0.03 to 4.0 μg/ml for 300…