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Antistaphylococcal Activity of Ceftobiprole, a New Broad-Spectrum Cephalosporin
Ceftobiprole is a novel cephalosporin with expanded activity against gram-positive bacteria and single-passage selections showed very low frequencies of resistance to ceftoiprole irrespective of genotype or phenotype. Expand
Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis
The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene. Expand
Activities of Gatifloxacin Compared to Those of Seven Other Agents against Anaerobic Organisms
ABSTRACT The agar dilution MIC was used to compare activities of gatifloxacin with those of ciprofloxacin, sparfloxacin, trovafloxacin, ampicillin, ampicillin-sulbactam, clindamycin, andExpand
Antipneumococcal Activity of ABT-773 Compared to Those of 10 Other Agents
ABT-773 shows promising in vitro activity against macrolide-susceptible as well as -resistant pneumococci, and had longer PAEs than macrolides, azithromycin, clindamycin, or β-lactams, including against ermB-containing strains. Expand
Susceptibilities of 228 penicillin- and erythromycin-susceptible and -resistant pneumococci to RU 64004, a new ketolide, compared with susceptibilities to 16 other agents.
RU 64004, a new ketolide, is the first member of the macrolide group which has low MICs for erythromycin-resistant pneumococci, and was very active against all strains tested, with MICs at which 90% of the isolates are inhibited. Expand
Antistaphylococcal Activity of Dalbavancin, an Experimental Glycopeptide
Dalbavancin was bactericidal at four times the MIC against all six strains tested, and tested against 146 staphylococci, was more potent than other drugs tested. Expand
Antistaphylococcal Activity of DX-619, a New Des-F(6)-Quinolone, Compared to Those of Other Agents
DX-619 has potent in vitro activity against staphylococci, including methicillin-, ciprofloxacin-, and vancomycin-resistant strains, and had the lowest mutation frequencies in single-step resistance selection. Expand
Antianaerobe Activity of RBX 7644 (Ranbezolid), a New Oxazolidinone, Compared with Those of Eight Other Agents
Ranbezolid had very good in vitro activity against both gram-negative and -positive anaerobes, and was compared with those of 11 other agents. Expand
Activities of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis
Time-kill analyses showed that ceftobiprole, ceftriaxone, cefpodoxime, amoxicillin-clavulanate, azithromycin, telithromyzin, and moxifloxacin were bactericidal at 2× MIC by 24 h against all 10 H. influenzae strains surveyed. Expand
Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis
Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2× MIC after 48 h. Expand