Kynurenine 3-monooxygenase

Known as: 3-Monooxygenase, Kynurenine, Kynurenine 3 Hydroxylase, Hydroxylase, Kynurenine 
An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3… (More)
National Institutes of Health

Papers overview

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2013
2013
Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (that is, kynurenine… (More)
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Highly Cited
2012
Highly Cited
2012
Increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. Here, we show… (More)
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Highly Cited
2011
Highly Cited
2011
Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to play an important role in… (More)
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Review
2011
Review
2011
There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has… (More)
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Highly Cited
2011
Highly Cited
2011
The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan… (More)
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Highly Cited
2011
Highly Cited
2011
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been implicated in the pathophysiology of… (More)
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Highly Cited
2008
Highly Cited
2008
Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core… (More)
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Highly Cited
2005
Highly Cited
2005
Huntington disease is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein huntingtin… (More)
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Highly Cited
2002
Highly Cited
2002
Macrophages exposed to macrophage colony-stimulating factor acquire the capacity to suppress T cell proliferation; this effect is… (More)
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Highly Cited
1992
Highly Cited
1992
Neurological dysfunction, seizures and brain atrophy occur in a broad spectrum of acute and chronic neurological diseases. In… (More)
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