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Kynurenine 3-monooxygenase

Known as: 3-Monooxygenase, Kynurenine, Kynurenine 3 Hydroxylase, Hydroxylase, Kynurenine 
An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3… 
National Institutes of Health

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8 relations
In BloodKMO geneProcess of secretionantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple… 
Highly Cited
2011
Highly Cited
2011
Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.
The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan… 
Review
2010
Review
2010
Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease.
Huntington's disease (HD) is an adult onset neurodegenerative disease caused by a polyglutamine expansion in the huntingtin… 
Highly Cited
2009
Highly Cited
2009
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo
In the mammalian brain, kynurenine aminotransferase II (KAT II) and kynurenine 3‐monooxygenase (KMO), key enzymes of the… 
Highly Cited
2004
Highly Cited
2004
The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression.
The mechanisms by which administration of interferon-alpha induces neuropsychiatric side effects, such as depressive symptoms and… 
Highly Cited
1999
Highly Cited
1999
Kynurenine metabolism in Alzheimer's disease
Summary. L-kynurenine (L-KYN) serves as a substrate for the synthesis of neurotoxic 3-OH-kynurenine (3-OH-KYN) and… 
Highly Cited
1997
Highly Cited
1997
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4… 
Highly Cited
1993
Highly Cited
1993
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
Highly Cited
1992
Highly Cited
1992
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
Immune activation leads to accumulations of the neurotoxin and kynurenine pathway metabolite quinolinic acid within the central… 
Highly Cited
1989
Highly Cited
1989
Characteristics of interferon induced tryptophan metabolism in human cells in vitro.
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