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Interaction of HapX with the CCAAT‐binding complex—a novel mechanism of gene regulation by iron
It is demonstrated that iron‐dependent pathways (e.g., heme biosynthesis) are repressed during iron‐depleted conditions by physical interaction of HapX with the CCAAT‐binding core complex (CBC), and that Hap X function is confined to iron‐ Depleted conditions. Expand
HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
It is demonstrated that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus, a opportunistic fungal pathogen facing iron starvation in the host. Expand
Tetrahydrobiopterin: biochemistry and pathophysiology.
A major contributor to vascular dysfunction associated with hypertension, ischaemic reperfusion injury, diabetes and others, appears to be an effect of oxidized BH4, which leads to an increased formation of oxygen-derived radicals instead of NO by decoupled NOS. Expand
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin*
- R. Heller, A. Unbehaun, B. Schellenberg, B. Mayer, G. Werner-Felmayer, E. Werner
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 5 January 2001
It is suggested that saturated ascorbic acid levels in endothelial cells are necessary to protect tetrahydrobiopterin from oxidation and to provide optimal conditions for cellular NO synthesis. Expand
Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.
- G. Brandacher, A. Perathoner, +11 authors A. Amberger
- Clinical cancer research : an official journal of…
- 15 February 2006
IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryPTophan catabolites. Expand
Iron regulates nitric oxide synthase activity by controlling nuclear transcription
- G. Weiss, G. Werner-Felmayer, E. Werner, K. Grünewald, H. Wachter, M. Hentze
- Biology, Medicine
- The Journal of experimental medicine
- 1 September 1994
The results suggest the existence of a regulatory loop between iron metabolism and the NO/NOS pathway, and nuclear run-off experiments demonstrate that nuclear transcription of cytokine-inducible NOS mRNA is strongly increased by desferrioxamine whereas it is decreased by Fe(3+). Expand
Nitric oxide synthase is induced in sporulation of Physarum polycephalum.
- G. Golderer, E. Werner, S. Leitner, P. Groebner, G. Werner-Felmayer
- Biology, Medicine
- Genes & development
- 15 May 2001
Cloned and sequenced this, the first nonanimal NOS to be identified, showing that it shares < 39% amino acid identity with known NOSs but contains conserved binding motifs for all NOS cofactors. Expand
SreA-mediated iron regulation in Aspergillus fumigatus
During iron‐replete conditions, SreA deficiency partially derepressed synthesis of triacetylfusarinine C and uptake of iron resulting in increased cellular accumulation of both iron and ferricrocin, underscoring that A.’fumigatus faces iron‐depleted conditions during infection. Expand
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.
- F. Cosentino, S. Patton, +5 authors T. Lüscher
- Medicine, Chemistry
- The Journal of clinical investigation
- 1 April 1998
Dysfunctional cNOS may be a source of O2- in prehypertensive SHR and contribute to the development of hypertension and its vascular complications. Expand
ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence
To understand the role of SrbA in fungal infection site pathobiology, chromatin immunoprecipitation followed by massively parallel DNA sequencing was used and identified a new transcriptional regulator of the fungal hypoxia response and virulence, SrbB. Expand