• Publications
  • Influence
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop.
TLDR
This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
TLDR
It was concluded that clinically manifest Parkinsonism represents the late, "decompensated", stage of a disease characterized by a progressive striatal DA deficiency; and the striatum can compensate functionally for lower degrees of DA deficiency.
Primary age-related tauopathy (PART): a common pathology associated with human aging
TLDR
A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)
TLDR
This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
TLDR
Evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of A&bgr; plaques and neurofibrillary tangles.
Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains
TLDR
Reduced glutathione and the shift of the iron (II)/iron (III) ratio in favor of iron ( III) suggest that these changes might contribute to pathophysiological processes underlying PD.
Alzheimer disease and cerebrovascular pathology: an update
  • K. Jellinger
  • Medicine
    Journal of Neural Transmission
  • 1 May 2002
TLDR
Small infarcts in AD patients have no essential impact on global cognitive decline which mainly depends on the severity of Alzheimer pathology, but in early stage of AD they may influence and promote the development of dementia.
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
TLDR
It is shown for the first time that insulin and c-peptide concentration in the brain are correlated and decrease with aging, as do brain insulin receptor densities, which favor the hypothesis that insulin dependent functions may be of pathogenetic relevance in sporadic Alzheimer's disease.
...
1
2
3
4
5
...