Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma
- C. Huber, J. R. Batchelor, H. Wachter
- BiologyJournal of Experimental Medicine
- 1 July 1984
It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
Iron regulates nitric oxide synthase activity by controlling nuclear transcription
- G. Weiss, G. Werner-Felmayer, E. Werner, K. Grünewald, H. Wachter, M. Hentze
- BiologyJournal of Experimental Medicine
- 1 September 1994
The results suggest the existence of a regulatory loop between iron metabolism and the NO/NOS pathway, and nuclear run-off experiments demonstrate that nuclear transcription of cytokine-inducible NOS mRNA is strongly increased by desferrioxamine whereas it is decreased by Fe(3+).
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis
- A. Díez-Ruiz, G. Tilz, R. Zangerle, G. Baier‐Bitterlich, H. Wachter, Dietmar Fuchs
- Biology, MedicineEuropean Journal of Haematology
- 1 January 1995
The available data imply that the measurement of sTNF‐Rs, especially of the sT NF‐R 75kD type, is a useful adjunct for quantification of the Th1‐type immune response, similar to other immune activation markers such as neopterin and β2‐microglobulin.
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
- G. Baier‐Bitterlich, F. Uberall, G. Baier
- BiologyMolecular and Cellular Biology
- 1 April 1996
Examination of the potential role of two representative PKC isoforms in the induction of the IL-2 gene shows PKC-theta as a specific constituent upstream of or parallel to Ras in the signaling cascade leading to AP transcriptional activation, and the critical AP-1 enhancer element was differentially modulated by these two distinct PKC isoenzymes.
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus
The results suggest that both vpr and nef are important for maximal SIV replication and persistence in vivo and for disease progression.
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
- G. Weiss, B. Goossen, M. Hentze
- BiologyEMBO Journal
- 1 September 1993
A novel role of NO is described as a signaling molecule in post‐transcriptional gene regulation and a regulatory connection between the NO/NOS pathway and cellular iron metabolism is identified.
The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases.
- D. Fuchs, G. Weiss, G. Reibnegger, H. Wachter
- Medicine, BiologyCritical reviews in clinical laboratory sciences
- 1992
Results of neopterin measurements agree with the important role that the cellular immune system plays in these disorders, including autoimmune disorders and certain malignant diseases.
Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase
- B. Mayer, Mathias John, E. Böhme
- BiologyFEBS Letters
- 19 August 1991
Neopterin, biochemistry and clinical use as a marker for cellular immune reactions.
- D. Fuchs, G. Weiss, H. Wachter
- Biology, MedicineInternational Archives of Allergy and Immunology
- 1993
Large amounts of neopterin are produced and released from human macrophages on stimulation with interferon-gamma, which allows insight into the immunopathogenesis of a variety of diseases.
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