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Open mass spectrometry search algorithm.
TLDR
The Open Mass Spectrometry Search Algorithm (OMSSA), designed to be faster than published algorithms in searching large MS/MS datasets, matches more spectra from a standard protein cocktail than a comparable algorithm. Expand
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
TLDR
The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan. Expand
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
TLDR
Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra. Expand
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
TLDR
Activated microglia and macrophage infiltrates into the brain might be an important source of accelerated conversion of L-tryptophan into quinolinic acid within the central nervous system in inflammatory diseases. Expand
Composition of the Synaptic PSD-95 Complex*S
TLDR
The identification of two Arf regulators, BRAG1 and BRAG2b, as co-purifying components of the complex implies pivotal functions in spine plasticity such as the reorganization of the actin cytoskeleton and insertion and retrieval of proteins to and from the plasma membrane. Expand
Light suppresses melatonin secretion in humans.
TLDR
Findings establish that the human response to light is qualitatively similar to that of other mammals. Expand
Glutaric aciduria; a "new" disorder of amino acid metabolism.
TLDR
It is speculated, but not proved, that the biochemical abnormality is causally related to the central nervous system dysfunction and compatible with an inherited deficiency of glutaryl-CoA dehydrogenase. Expand
Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
TLDR
It is reported here that MPTP is oxidized in the brain to a pyridinium species (a compound with potent herbicidal activity) and, in the monkey, is trapped intraneuronally and demonstrated that this enzymatic oxidation is blocked in vivo in the mouse by a monoamine oxidase inhibitor, indicating that the oxidative metabolism is required for its neurotoxic effect. Expand
Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages
TLDR
Glutamate measured in CM accounted for all neurotoxic effects observed from HIV/LPS CM in astrocyte-poor neuronal cultures and may contribute to the pathophysiology of HIV-1-associated dementia. Expand
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
TLDR
Increased activities of kynurenine pathway enzymes in various tissues following systemic immune stimulation, in conjunction with macrophage infiltration of the affected tissue, provide a mechanism to account for increased concentrations of quinolinic acid. Expand
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