Kynurenate

 
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Excessive activation of NMDA receptors results in excitotoxic nerve cell loss, which is believed to play a critical role in the… (More)
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2003
2003
In the rodent brain, astrocytes are known to be the primary source of kynurenate (KYNA), an endogenous antagonist of both the… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Metabolites of the kynurenine pathway of tryptophan degradation may play a role in the pathogenesis of several human… (More)
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Highly Cited
2001
Highly Cited
2001
Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic glutamate and alpha7 nicotinic… (More)
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Highly Cited
1997
Highly Cited
1997
The role of transporters in clearing free glutamate from the synaptic cleft was studied in rat CA1 hippocampal neurons cultured… (More)
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Review
1993
Review
1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical… (More)
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Highly Cited
1989
Highly Cited
1989
Membranes from rat telencephalon contain a single class of strychnine-insensitive glycine sites. That these sites are associated… (More)
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1988
1988
The antagonist profile of kynurenate and FG9041 have been characterised in a modified preparation of the baby rat hemisected… (More)
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Highly Cited
1988
Highly Cited
1988
The antagonist pharmacology of glutamate neurotoxicity was quantitatively examined in murine cortical cell cultures. Addition of… (More)
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1987
1987
Pharmacological inhibition of excitatory neurotransmission attenuates cell death in models of global ischemia/reperfusion and… (More)
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