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Endocannabinoid-mediated control of synaptic transmission.
This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling. Expand
The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission
Endocannabinoids are released from postsynaptic neurons and cause retrograde suppression of synaptic transmission. Anandamide and 2-arachidonoylglycerol (2-AG) are regarded as two majorExpand
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
It is concluded that mGLUR1 is required for the induction of LTD and that the ataxic behavior and impaired eyeblink conditioning of the mGluR1 mutant mice are primarily due to deficient LTD. Expand
Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum
2-AG is identified as the major endocannabinoid mediating retrograde suppression at excitatory and inhibitory synapses of MS neurons, and CB1 cannabinoid receptor, the main target of 2-AG, was present at high levels on GABAergic axon terminals of MS neuron and parvalbumin-positive interneurons and at low levels on excitatories corticostriatal afferents. Expand
Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic Terminals
The results reveal that endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals to cause the reduction of transmitter release. Expand
The CB1 Cannabinoid Receptor Is the Major Cannabinoid Receptor at Excitatory Presynaptic Sites in the Hippocampus and Cerebellum
Electrophysiological and immunohistochemical data and morphological data indicate that CB1 is responsible for cannabinoid-dependent suppression of excitatory transmission in the hippocampus and cerebellum. Expand
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
  • K. Watase, Kouichi Hashimoto, +11 authors Kohichi Tanaka
  • Biology, Medicine
  • The European journal of neuroscience
  • 1 March 1998
Results indicate that GLAST plays active roles both in the cerebellar climbing fibre synapse formation and in preventing excitotoxic Cerebellar damage after acute brain injury. Expand
Localization of Diacylglycerol Lipase-α around Postsynaptic Spine Suggests Close Proximity between Production Site of an Endocannabinoid, 2-Arachidonoyl-glycerol, and Presynaptic Cannabinoid CB1
The results indicate that DAGLα is essentially targeted to postsynaptic spines in cerebellar and hippocampal neurons, but its fine distribution within and around spines is differently regulated between the two neurons. Expand
Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons and is detected by phospholipase Cbeta1 in hippocampusal neurons. Expand
Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors
A signaling mechanism whereby activation of postsynaptic mGluR retrogradely influences presynaptic functions via endocannabinoid system is highlighted, which can be initiated by two distinct stimuli. Expand