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NMDA receptor subunits: diversity, development and disease
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Role of Distinct NMDA Receptor Subtypes at Central Synapses
TLDR
This Review covers recent research that has started to provide perspective into some of the discrete tasks carried out by individual receptor subtypes in NMDA receptors.
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Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance
TLDR
The results highlight the importance of tonic inhibition mediated by GABAA receptors, loss of which triggers a form of homeostatic plasticity leading to a change in the magnitude of a voltage-independent K + conductance that maintains normal neuronal behaviour.
View on Nature
Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude
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Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ
TLDR
High-resolution recordings of spontaneous miniature excitatory postsynaptic currents in granule cells show no evidence for the recent proposal that miniature currents ingranule cells are mediated solely by NMDA channels with a novel time course, and the non-NMDA receptor component of m.p.e.s.s-cs has a skewed amplitude distribution, which suggests potential complications for quantal analysis.
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Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
TLDR
It is shown here thatNMDA receptor responses are selectively inhibited by protons, with a 50% inhibitory concentration (IC50) that is close to physiological pH, implying that NMDA receptors are not fully active under normal conditions.
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Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
TLDR
A new form of synaptic plasticity is described—a rapid and lasting change in the subunit composition and Ca2+ permeability of AMPARs at cerebellar stellate cell synapses following synaptic activity.
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Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond
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Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse
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Developmental Profile of the Changing Properties of NMDA Receptors at Cerebellar Mossy Fiber–Granule Cell Synapses
TLDR
The data are consistent with the known switch from NR2B toNR2A to NR2A subunits during the first two postnatal weeks, but suggest a gradual incorporation of the NR2C subunit that modifies Mg2+ sensitivity and only later influences EPSC kinetics.
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