Kynurenic Acid

Known as: 2-Quinolinecarboxylic acid, 4-hydroxy-, Acid, Kynurenic, Kynurenic Acid [Chemical/Ingredient] 
A broad-spectrum excitatory amino acid antagonist used as a research tool.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1949-2018
010203019492017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The kynurenine pathway of tryptophan metabolism is involved in the pathogenesis of several brain diseases, but its physiological… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2011
2011
Kynurenic acid (KYNA), an astrocyte-derived metabolite, antagonizes the α7 nicotinic acetylcholine receptor (α7nAChR) and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the α7 nicotinic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2009
2009
The cognitive deficits seen in schizophrenia patients are likely related to abnormal glutamatergic and cholinergic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2009
2009
The therapeutic effect of Cerebrolysin in the treatment of dementia and brain injury has been proposed because of neurotrophic… (More)
  • table 1
  • figure 1
  • table 2
Is this relevant?
2003
2003
Brain levels of kynurenic acid (KYNA), an endogenous antagonist of glycineB/NMDA and α-7 nicotinic acetylcholine receptors, are… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
2003
2003
The mode of action by which the atypical antipsychotic drug clozapine exerts its superior efficacy to ameliorate both positive… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1992
1992
The present study was designed to examine the cellular localization and biosynthetic machinery of the broad-spectrum excitatory… (More)
Is this relevant?