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Kynurenic Acid

Known as: 2-Quinolinecarboxylic acid, 4-hydroxy-, Acid, Kynurenic, Kynurenic Acid [Chemical/Ingredient] 
A broad-spectrum excitatory amino acid antagonist used as a research tool.
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (12)

3-hydroxyquinaldic acid4,6,8-trihydroxyquinaldic acid4,6-dichlorokynurenine4-quinolone-2-carboxylic acid

Broader (1)

Excitatory Amino Acid Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Presence of kynurenic acid in food and honeybee products
Kynurenic acid (KYNA) is an endogenous antagonist of ionotropic glutamate receptors and the α7 nicotinic acetylcholine receptor… 
Highly Cited
2007
Highly Cited
2007
Elevations of endogenous kynurenic acid produce spatial working memory deficits.
Kynurenic acid (KYNA) is a tryptophan metabolite that is synthesized and released by astrocytes and acts as a competitive… 
Highly Cited
2003
Highly Cited
2003
Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat
Brain levels of kynurenic acid (KYNA), an endogenous antagonist of glycineB/NMDA and α-7 nicotinic acetylcholine receptors, are… 
Highly Cited
1996
Highly Cited
1996
Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection.
Highly Cited
1993
Highly Cited
1993
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
Highly Cited
1992
Highly Cited
1992
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Highly Cited
1990
Highly Cited
1990
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors
Excitatory amino acid (EAA)-mediated synaptic transmission is the most prevalent excitatory system within the mammalian brain… 
Highly Cited
1989
Highly Cited
1989
Stimulation-dependent release of adenosine triphosphate from hippocampal slices
Highly Cited
1989
Highly Cited
1989
Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis
Highly Cited
1987
Highly Cited
1987
Role of excitatory amino acids in rat vagal and sympathetic baroreflexes
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