CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism
@article{Brickley2001CNQXIG, title={CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism}, author={Stephen G Brickley and Mark Farrant and G T Swanson and S. G. Cull-Candy}, journal={Neuropharmacology}, year={2001}, volume={41}, pages={730-736} }
65 Citations
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The absence of AMPAR-mediated effects in recordings from stargazer dissociated Purkinje cells, suggests that presynaptic AMPARs do not function without γ-2-association, which is identified as a crucial subunit for presyn synaptic modulation of GABA release that occurs via regulation of VGCCs remote from active zones.
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Hypoxia is the most common cause of perinatal seizures and can be refractory to conventional anticonvulsant drugs, suggesting an age-specific form of epileptogenesis. A model of hypoxia-induced…
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The data suggest that the consolidation of the avoidance memory requires intact non-NMDA receptor function in the hippocampus and the basolateral nucleus of the amygdala, but not necessarily in the entorhinal and parietal cortex, for long periods after training.
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The rate, amplitude, and kinetics of GABA(A,fast) mIPSCs showed significant changes between P10 and P30, suggesting counterbalancing changes in action potential-dependent inhibitory postsynaptic currents in IPSCs, consistent with the hypothesis that developmental changes in GABA (A,slow) IPSCs are due to changes in presynaptic excitability.
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