Knock-out

Known as: Knockout 
Inactivation of specific genes by homologous recombination. Knockouts are often created in laboratory organisms such as yeast or mice so that… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a key… (More)
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Highly Cited
2006
Highly Cited
2006
P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located… (More)
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Highly Cited
2006
Highly Cited
2006
The "classical" organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the… (More)
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Highly Cited
2003
Highly Cited
2003
The physiological roles of neuronal gap junctions in the intact brain are not known. The recent generation of the connexin-36… (More)
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Highly Cited
2002
Highly Cited
2002
Selective blockers of the norepinephrine transporter (NET) inhibit dopamine uptake in the prefrontal cortex. This suggests that… (More)
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Highly Cited
2002
Highly Cited
2002
Endogenous cannabinoid signaling pathways have been implicated in protection of the brain from hypoxia, ischemia, and trauma, but… (More)
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Highly Cited
2001
Highly Cited
2001
Deleterious processes of extracellular proteolysis may contribute to the progression of tissue damage after acute brain injury… (More)
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Highly Cited
2001
Highly Cited
2001
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using… (More)
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Highly Cited
2000
Highly Cited
2000
Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance in the nervous system (Decker et al., 1995… (More)
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Highly Cited
1999
Highly Cited
1999
Glucokinase (GK) gene mutations cause diabetes mellitus in both humans and mouse models, but the pathophysiological basis is only… (More)
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