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Knock-out

Known as: Knockout 
Inactivation of specific genes by homologous recombination. Knockouts are often created in laboratory organisms such as yeast or mice so that… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
MicroRNA miR-150 Is Involved in Vα14 Invariant NKT Cell Development and Function
CD1d-restricted Vα14 invariant NKT (iNKT) cells play an important role in the regulation of diverse immune responses. MicroRNA… 
Highly Cited
2009
Highly Cited
2009
FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle.
The plasma membrane fatty acid transport protein FAT/CD36 is also present at the mitochondria, where it may contribute to the… 
Highly Cited
2008
Highly Cited
2008
Evidence of Missense Mutations on the Neuregulin 1 Gene Affecting Function of Prepulse Inhibition
Highly Cited
2008
Highly Cited
2008
Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.
Carney complex (CNC) is an inherited neoplasia syndrome characterized by spotty skin pigmentation, myxomas, endocrine tumors, and… 
Highly Cited
2005
Highly Cited
2005
Role of interferon-γ in a mouse model of allergic conjunctivitis
Purpose To characterize the effect of repeated topical exposure to allergen in a mouse model of allergic conjunctivitis and to… 
Review
2003
Review
2003
Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting
Summary:  Mice with inactivation of lymphotoxin β receptor (LTβR) system have profound defects in the development and maintenance… 
Highly Cited
2003
Highly Cited
2003
Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing
In contrast to adult cutaneous wound repair, early gestational fetal cutaneous wounds heal by a process of regeneration… 
Highly Cited
2002
Highly Cited
2002
A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse.
Pharmacological analysis alone has failed to clarify the role of the three alpha(1)-adrenoceptor subtypes in modulating vascular… 
Highly Cited
1999
Highly Cited
1999
Immune-stimulating complexes induce an IL-12-dependent cascade of innate immune responses.
The development of subunit vaccines requires the use of adjuvants that act by stimulating components of the innate immune… 
Highly Cited
1998
Highly Cited
1998
Absence of Fenfluramine-Induced Anorexia and Reduced c-fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice
Fenfluramine, a serotonin releaser and uptake inhibitor, has been widely prescribed as an appetite suppressant. Despite its… 
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