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Knock-out

Known as: Knockout 
Inactivation of specific genes by homologous recombination. Knockouts are often created in laboratory organisms such as yeast or mice so that… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Loss of Protein Kinase Novel 1 (PKN1) is Associated with Mild Systolic and Diastolic Contractile Dysfunction, Increased Phospholamban Thr Phosphorylation and Exacerbated Ischaemia-Reperfusion Injury
Citation for published version (APA): Francois, A. A., Obasanjo-Blackshire, K., Clark, J. E., Boguslavskyi, A., Holt, M. R… 
2016
2016
Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.
Nitric oxide (NO) inhibits collecting duct (CD) Na+ and water reabsorption. Mice with CD-specific knockout (KO) of NO synthase 1… 
2012
2012
mPGES-1 deletion potentiates urine concentrating capability after water deprivation.
PGE(2) plays an important role in the regulation of fluid metabolism chiefly via antagonizing vasopressin-induced osmotic… 
2012
2012
Use of Praziquantel as an Adjuvant Enhances Protection and Tc-17 Responses to Killed H5N1 Virus Vaccine in Mice
Background H5N1 is a highly pathogenic influenza A virus, which can cause severe illness or even death in humans. Although the… 
2011
2011
Genetic deletion of the P 2 Y 2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE 2 signaling
Zhang Y, Pop IL, Carlson NG, Kishore BK. Genetic deletion of the P2Y2 receptor offers significant resistance to development of… 
2010
2010
PGC-1 (cid:1) increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
PGC-1 (cid:1) increases PDH content but does not change acute PDH regulation in mouse skeletal muscle. The aim of this study was… 
2009
2009
Hunting for the SNARK in metabolic disease.
dysregulation of energy balance is a primary constituent in the etiology of obesity and type 2 diabetes mellitus, which is… 
2007
2007
Production and Characterization of Transgenic Mice Systemically Expressing Endo-β-galactosidase C
The αGal epitope (Galα1-3Gal) is a sugar structure expressed on the cell surface of almost all organisms except humans and old… 
2006
2006
An unusual pro-inflammatory role of interleukin-10 induced by arabinosylated lipoarabinomannan in murine peritoneal macrophages
Various species of Mycobacteria produce a major cell wall-associated lipoglycan, called Lipoarabinomannan (LAM), which is… 
2003
2003
Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S 6 Kinase 2
The p90 ribosomal S6 kinase 2 (RSK2) is a serine/ threonine kinase with high expression levels in adipose tissue. Numerous in…