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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
Macrophages (mφ) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete mφ populations carry out these distinct functionsExpand
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Oral tolerance to food protein
Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins. An analogous but more local process alsoExpand
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CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.
Dendritic cells (DCs) and monocyte-derived macrophages (MΦs) are key components of intestinal immunity. However, the lack of surface markers differentiating MΦs from DCs has hampered understanding ofExpand
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Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells
Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinalExpand
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Correction: Corrigendum: Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
Nat. Immunol. doi:10.1038/ni.2967 corrected online 8 September 2014 In the version of this article initially published online, the vertical axis of the bottom right graph in Figure 3h was incorrect.Expand
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Intestinal CD103+ dendritic cells: master regulators of tolerance?
CD103(+) dendritic cells (DCs) in the intestinal mucosa play a crucial role in tolerance to commensal bacteria and food antigens. These cells originate in the lamina propria (LP) and migrate to theExpand
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The anatomical basis of intestinal immunity
Summary: The lymphoid tissues associated with the intestine are exposed continuously to antigen and are the largest part of the immune system. Many lymphocytes are found in organised tissues such asExpand
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Macrophages in intestinal homeostasis and inflammation
The intestine contains the largest pool of macrophages in the body which are essential for maintaining mucosal homeostasis in the face of the microbiota and the constant need for epithelial renewalExpand
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Immunomodulatory dendritic cells in intestinal lamina propria.
The lamina propria (LP) of the small intestine contains many dendritic cells (DC), which are likely to be in close contact with luminal antigens, but their role in intestinal immune responses hasExpand
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Expanding dendritic cells in vivo enhances the induction of oral tolerance.
The intestine is under perpetual challenge from both pathogens and essential nutrients, yet the mucosal immune system is able to discriminate effectively between harmful and innocuous Ags. It isExpand
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