• Publications
  • Influence
Role of Elastin in Spontaneously Hypertensive Rat Small Mesenteric Artery Remodelling
Chronic hypertension is associated with resistance artery remodelling and mechanical alterations. However, the contribution of elastin has not been thoroughly studied. Our objective was to evaluateExpand
  • 131
  • 8
  • PDF
A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse.
Pharmacological analysis alone has failed to clarify the role of the three alpha(1)-adrenoceptor subtypes in modulating vascular tone, due to a lack of sufficiently selective antagonists,Expand
  • 78
  • 7
  • PDF
Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid‐like’ receptors in small arteries
Background and purpose:  Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors are located in the same cells. We haveExpand
  • 86
  • 5
Fluorescent ligands for the study of receptors.
  • 94
  • 4
Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor*
α1-Adrenergic receptors (α1A, α1B, and α1D) are regulators of systemic arterial blood pressure and blood flow. Whereas vasoconstrictory action of the α1A and α1D subtypes is thought to be mainlyExpand
  • 89
  • 4
Direct demonstration of β1‐ and evidence against β2‐ and β3‐adrenoceptors, in smooth muscle cells of rat small mesenteric arteries
Recent evidence supports additional subtypes of vasodilator β‐adrenoceptor (β‐AR) besides the ‘classical’ β2. The aim of this study was to investigate the distribution of β‐ARs in the wall of ratExpand
  • 55
  • 4
Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries.
1 Recent evidence supports additional subtypes of vasodilator beta-adrenoceptor (beta-AR) besides the 'classical' beta(2). The aim of this study was to investigate the distribution of beta-ARs in theExpand
  • 29
  • 4
Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites.
Cellular distribution and binding characteristics of native alpha(1)-adrenoceptors (ARs) were determined in a live, single, human smooth muscle cell (SMC) with confocal laser scanning microscopy andExpand
  • 67
  • 3
β-Arrestin-Dependent Spontaneous α1a-Adrenoceptor Endocytosis Causes Intracellular Transportation of α-Blockers via Recycling Compartmentss⃞
The antagonist ligand BODIPY-FL-prazosin (QAPB) fluoresces when bound to bovine α1a-adrenoceptors (ARs). Data indicate that the receptor-ligand complex is spontaneously internalized byExpand
  • 44
  • 3
Insights into the functional roles of α1‐adrenoceptor subtypes in mouse carotid arteries using knockout mice
1 α1‐Adrenoceptor (AR) subtypes in mouse carotid arteries were characterised using a combination of agonist/antagonist pharmacology and knockout (KO) mice. 2 Phenylephrine (PE) was most potent in theExpand
  • 24
  • 3