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Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
It is shown that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished, which is indicative of enhanced pattern separation.
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
MRI measurements of cerebral blood volume provide an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging are shown.
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
The findings show that adult-born neurons make a distinct contribution to some but not all hippocampal functions and show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior.
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Findings show that postnatal developmental processes help to establish adult anxiety-like behaviour, and the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood.
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
A critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult is indicated and a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders is suggested.
Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression
Several novel effects of chronic, but not subchronic, antidepressant treatment are presented, including increased swimming and reduced immobility in the forced swim test and anxiety-related measures were reduced by 18 mg/kg/day.
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
  • S. Ramboz, R. Oosting, R. Hen
  • Biology, Psychology
    Proceedings of the National Academy of Sciences…
  • 24 November 1998
It is demonstrated that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces) and suggested that reductions in 5- HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.