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Ketoconazole
Known as:
Ketoconazolum
, Ketoconazol
, Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-
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A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a…
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National Institutes of Health
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Related topics
Related topics
42 relations
24 HR Nevirapine 400 MG Extended Release Oral Tablet
Antifungal Agents
Astemizole
Azoles
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Broader (2)
Cytochrome P-450 CYP3A Inhibitors
Imidazoles
Narrower (7)
Extina
Ketoderm
Ketozole
Mal-A-Ket
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.
C. Ryan
,
Matthew R. Smith
,
+9 authors
E. Small
Journal of Clinical Oncology
2010
Corpus ID: 26858321
PURPOSE Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential…
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Highly Cited
2010
Highly Cited
2010
Antibacterial, antifungal, and antiviral activities of some flavonoids.
D. D. Orhan
,
B. Ozçelik
,
Selda Ozgen
,
F. Ergun
Microbiology Research
2010
Corpus ID: 22032014
Highly Cited
2004
Highly Cited
2004
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583).
E. Small
,
S. Halabi
,
+7 authors
N. Vogelzang
Journal of Clinical Oncology
2004
Corpus ID: 1892422
PURPOSE Antiandrogen withdrawal (AAWD) results in a prostate-specific antigen (PSA) response (decline in PSA level of > or =50…
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Review
2001
Review
2001
Screening for human ADME/Tox drug properties in drug discovery.
Albert P. Li
Drug Discovery Today
2001
Corpus ID: 46441373
Review
2000
Review
2000
In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs.
J. Dressman
,
C. Reppas
European Journal of Pharmaceutical Sciences
2000
Corpus ID: 21619733
Highly Cited
1999
Highly Cited
1999
Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169…
C. Wolf
,
C. Lambright
,
+4 authors
L. Gray
Toxicology and industrial health
1999
Corpus ID: 43602740
Antiandrogenic chemicals alter sexual differentiation by a variety of mechanisms, and as a consequence, they induce different…
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Highly Cited
1993
Highly Cited
1993
Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences.
Peter K. Honig
,
Dale C. Wortham
,
K. Zamani
,
Dale P. Conner
,
J. Mullin
,
L. Cantilena
Journal of the American Medical Association (JAMA…
1993
Corpus ID: 34145202
OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization…
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Highly Cited
1983
Highly Cited
1983
Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.
D. Loose
,
P. B. Kan
,
Margaret A. Hirst
,
R. Marcus
,
David Feldman
Journal of Clinical Investigation
1983
Corpus ID: 22820570
Ketoconazole has recently been shown to interfere with steroidogenesis in patients and rat in vitro systems. In this study we…
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Highly Cited
1982
Highly Cited
1982
Ketoconazole blocks testosterone synthesis.
A. Pont
,
P. Williams
,
+4 authors
D. Stevens
Archives of Internal Medicine
1982
Corpus ID: 11734762
Ketoconazole, a new oral drug used to treat systemic and superficial mycoses, inhibits sterol synthesis in fungi. The development…
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Highly Cited
1982
Highly Cited
1982
Ketoconazole blocks adrenal steroid synthesis.
A. Pont
,
P. L. Williams
,
+4 authors
D. Stevens
Annals of Internal Medicine
1982
Corpus ID: 24687210
Ketoconazole, a broad-spectrum, antifungal drug that is administered orally, has been shown to inhibit sterol synthesis in fungi…
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