Ketoconazole

Known as: Ketoconazolum, Ketoconazol, Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis- 
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a… (More)
National Institutes of Health

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1950-2017
010020019502016

Papers overview

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Highly Cited
2010
Highly Cited
2010
PURPOSE Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential… (More)
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Highly Cited
2007
Highly Cited
2007
Prasugrel and clopidogrel inhibit platelet aggregation through active metabolite formation. Prasugrel's active metabolite (R… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Antiandrogen withdrawal (AAWD) results in a prostate-specific antigen (PSA) response (decline in PSA level of > or =50… (More)
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Highly Cited
2001
Highly Cited
2001
The glass forming properties of ketoconazole were investigated using differential scanning calorimetry (DSC), by quench cooling… (More)
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Highly Cited
1999
Highly Cited
1999
Antiandrogenic chemicals alter sexual differentiation by a variety of mechanisms, and as a consequence, they induce different… (More)
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To quantitate the effect of ketoconazole, an azole antifungal agent and potent inhibitor of CYP3A4 and P-glycoprotein… (More)
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Highly Cited
1995
Highly Cited
1995
1. The potential of ketoconazole and sulphaphenazole to inhibit specific P450 enzyme activities (1A2, 2A6, 2B6, 2C9/8, 2C19, 2D6… (More)
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Highly Cited
1994
Highly Cited
1994
Interaction between ketoconazole, itraconazole, and midazolam was investigated in a double-blind, randomized crossover study of… (More)
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Highly Cited
1993
Highly Cited
1993
OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization… (More)
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Highly Cited
1988
Highly Cited
1988
Ketoconazole, an antifungal antibiotic, inhibits cholesterol synthesis by blocking demethylation of lanosterol. Effects of this… (More)
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