This review summarizes recent developments in understanding of the antimicrobial and anti-inflammatory activities of the tea tree oil and its components, as well as clinical efficacy.Expand
The predisposition to lysis, the loss of 260-nm-absorbing material, the lost of tolerance to NaCl, and the altered morphology seen by electron microscopy all suggest that tea tree oil and its components compromise the cytoplasmic membrane.Expand
The antimicrobial activity of eight components of tea tree oil was evaluated using disc diffusion and broth microdilution methods and reasonable agreement between minimum inhibitory concentrations and zones of inhibition was found.Expand
The objective is to investigate the in vitro antifungal activity of the components of Melaleuca alternifolia (tea tree) oil to find out if it acts as a ‘spatially aggregating agent’ or ‘neutralizer’ to fungi.Expand
All 66 isolates of Staphylococcus aureus tested were susceptible to the essential oil of Melaleuca alternifolia, or tea tree oil, in disc diffusion and modified broth microdilution methods, suggestingTea tree oil may be useful in the treatment of MRSA carriage.Expand
The water-soluble components of tea tree oil can suppress pro-inflammatory mediator production by activated human monocytes and reduce the production in vitro of tumour necrosis factor-α, IL-1β and IL-10 by lipopolysaccharide-activated human peripheral blood monocytes.Expand
A broth micro-dilution method was used to examine the susceptibility of Escherichia coli and Staphylococcus aureus to the essential oil of Melaleuca alternifolia (tea tree oil) to enhance the solubility of tea tree oil in the test medium.Expand
Data from individual components suggest that TTO has the potential to be developmentally toxic if ingested at higher doses, however, TTO and its components are not genotoxic.Expand
Data from this study support the hypothesis that tea tree oil and components exert their antifungal actions by altering membrane properties and compromising membrane-associated functions.Expand