The development of androgen-independent prostate cancer
- B. Feldman, D. Feldman
- MedicineNature Reviews. Cancer
- 1 October 2001
It is predicted that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers.
The role of vitamin D in reducing cancer risk and progression
- D. Feldman, A. Krishnan, S. Swami, E. Giovannucci, B. Feldman
- Medicine, BiologyNature Reviews. Cancer
- 1 May 2014
Accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome.
Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.
- A. Krishnan, P. Stathis, S. F. Permuth, L. Tőkés, D. Feldman
- BiologyEndocrinology
- 1 June 1993
The findings raise the possibility that unsuspected estrogenic activity in the form of BPA may have an impact on experiments employing media autoclaved in polycarbonate flasks, and it remains to be determined whether BPA derived from consumer products manufactured from poly carbonate could significantly contribute to the pool of estrogenic substances in the environment.
Unraveling insulin-like growth factor binding protein-3 actions in human disease.
- Sherryline Jogie‐Brahim, D. Feldman, Y. Oh
- Biology, MedicineEndocrine reviews
- 1 August 2009
This review reinforces the concept in support of the IGF/IGF-IR axis-independent actions of IGF BP-3 and delineates potential underlying mechanisms involved and subsequent biological significance, focusing in particular on functional binding partners and the clinical significance of IGFBP-3 in the assessment of cancer risk.
Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.
- A. Krishnan, D. Feldman
- Biology, MedicineAnnual Review of Pharmacology and Toxicology
- 6 January 2011
Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro-differentiating actions on various malignant cells and retards tumor growth in animal models of cancer.
The Vitamin D Receptor Start Codon Polymorphism (FokI) and Bone Mineral Density in Premenopausal American Black and White Women
- S. Harris, T. R. Eccleshall, C. Gross, B. Dawson-Hughes, D. Feldman
- Biology, MedicineJournal of Bone and Mineral Research
- 1 July 1997
The SCP polymorphism, detected with the endonuclease FokI, appears to influence peak bone density, particularly at the femoral neck, particularly in premenopausal American women.
The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets.
- P. Malloy, J. Pike, D. Feldman
- Biology, ChemistryEndocrine reviews
- 1 April 1999
The VDR Gene and the Molecular Basis of HVDRR, a syndrome of Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets, and Mutations Causing the Ligand-Binding Negative Phenotype, are described.
Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines.
- R. Skowroński, D. Peehl, D. Feldman
- Biology, MedicineEndocrinology
- 1 May 1993
It is demonstrated that these three human prostate carcinoma cell lines all possess specific VDR and that 1,25(OH)2D3 treatment can elicit both an antiproliferative and a differentiating action on these cancer cells, lending support to the hypothesis that vitamin D might exert beneficial actions on prostate cancer risk.
Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.
- Lihong Peng, P. Malloy, D. Feldman
- BiologyMolecular Endocrinology
- 1 May 2004
The purpose of this study was to determine the molecular mechanism involved in 1,25-(OH)2D3 regulation of IGFBP-3 expression and to identify the putative vitamin D response element (VDRE) in the IGF BP-3 promoter to identify a functional VDRE in the distal region of the human IGFBP -3 promoter.
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment.
- A. Krishnan, D. Feldman
- Biology, MedicineEndocrine-Related Cancer
- 1 March 2010
It is hypothesized that anti-inflammatory actions of calcitriol play an important role in its potential use as a therapeutic agent for PCa and should be evaluated in clinical trials in PCa patients with early or precancerous disease.
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