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The development of androgen-independent prostate cancer
It is predicted that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers. Expand
Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.
- A. Krishnan, P. Stathis, S. F. Permuth, L. Tőkés, D. Feldman
- Chemistry, Medicine
- 1 June 1993
The findings raise the possibility that unsuspected estrogenic activity in the form of BPA may have an impact on experiments employing media autoclaved in polycarbonate flasks, and it remains to be determined whether BPA derived from consumer products manufactured from poly carbonate could significantly contribute to the pool of estrogenic substances in the environment. Expand
The role of vitamin D in reducing cancer risk and progression
- D. Feldman, A. Krishnan, S. Swami, E. Giovannucci, B. Feldman
- Nature Reviews Cancer
- 1 May 2014
Accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome. Expand
Unraveling insulin-like growth factor binding protein-3 actions in human disease.
This review reinforces the concept in support of the IGF/IGF-IR axis-independent actions of IGF BP-3 and delineates potential underlying mechanisms involved and subsequent biological significance, focusing in particular on functional binding partners and the clinical significance of IGFBP-3 in the assessment of cancer risk. Expand
Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.
Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro-differentiating actions on various malignant cells and retards tumor growth in animal models of cancer. Expand
The Vitamin D Receptor Start Codon Polymorphism (FokI) and Bone Mineral Density in Premenopausal American Black and White Women
- S. Harris, T. R. Eccleshall, C. Gross, B. Dawson-Hughes, D. Feldman
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 July 1997
The SCP polymorphism, detected with the endonuclease FokI, appears to influence peak bone density, particularly at the femoral neck, particularly in premenopausal American women. Expand
The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets.
The VDR Gene and the Molecular Basis of HVDRR, a syndrome of Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets, and Mutations Causing the Ligand-Binding Negative Phenotype, are described. Expand
Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines.
It is demonstrated that these three human prostate carcinoma cell lines all possess specific VDR and that 1,25(OH)2D3 treatment can elicit both an antiproliferative and a differentiating action on these cancer cells, lending support to the hypothesis that vitamin D might exert beneficial actions on prostate cancer risk. Expand
Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.
The purpose of this study was to determine the molecular mechanism involved in 1,25-(OH)2D3 regulation of IGFBP-3 expression and to identify the putative vitamin D response element (VDRE) in the IGF BP-3 promoter to identify a functional VDRE in the distal region of the human IGFBP -3 promoter. Expand
Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol.
- N. Madani, P. Malloy, P. Rodríguez-Pombo, A. Krishnan, D. Feldman
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 1994
The cloning and complete nucleotide sequence of a gene encoding a C. albicans EBP was reported, which has no evident homology to the mammalian steroid receptor superfamily but appears to be a member of a recently identified family of flavoproteins. Expand