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KLRK1 wt Allele

Known as: FLJ75772, KLR, FLJ17759 
Human KLRK1 wild-type allele is located within 12p13.2-p12.3 and is approximately 19 kb in length. This allele, which encodes NKG2-D type II integral… 
National Institutes of Health

Related topics

Related topics

7 relations
12p13.2-p12.3Ligand BindingNK Cell ActivationNKG2-D Type II Integral Membrane Protein

Broader (1)

KLRK1 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell.
Review
2012
Review
2012
Cancer immunotherapy using NKG2D and DNAM-1 systems.
Although tumor antigen-specific immunotherapy, such as dendritic cell vaccine, has recently emerged as a promising clinical… 
2010
2010
Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus
This study aims to explore the percentage of T-cell and NK-cell subsets, the expression of NKG2A and NKG2D on CD3+ T cells and… 
Highly Cited
2009
Highly Cited
2009
Oxidative Stress Mediates a Reduced Expression of the Activating Receptor NKG2D in NK Cells from End-Stage Renal Disease Patients1
To characterize the immune defect of patients with end-stage renal disease (ESRD), we performed NK cell subset analysis in 66… 
2008
2008
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
It has been recently demonstrated that NKG2D is an activating costimulatory receptor on natural killer (NK) cells, natural killer… 
Highly Cited
2007
Highly Cited
2007
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
Monocyte-derived dendritic cells (mDCs) and NK cells are reciprocally activate via cytokines and cell-cell contact. Although… 
Highly Cited
2007
Highly Cited
2007
Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse1
NKG2D is an activating receptor expressed on all human NK cells and a subset of T cells. In cytolytic conjugates between NK cells… 
Highly Cited
2007
Highly Cited
2007
Heightened Expression of the Cytotoxicity Receptor NKG2D Correlates with Acute and Chronic Nephropathy After Kidney Transplantation
The activating cytotoxicity receptor NKG2D binds to stress‐regulated molecules encoded by the major histocompatibility complex… 
Highly Cited
2006
Highly Cited
2006
Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics1
The NK cell-activating receptor NKG2D recognizes several MHC class I-related molecules expressed on virally infected and tumor… 
Review
2004
Review
2004
NKG2D and Related Immunoreceptors.
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