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KLRK1 gene

Known as: KLR, killer cell lectin like receptor K1, KLRK1 
This gene plays a role in the activation of natural killer cells.
National Institutes of Health

Related topics

Related topics

8 relations
KLRG1 geneLigand BindingNK Cell ActivationNKG2-D Type II Integral Membrane Protein

Narrower (2)

KLRK1 wt AlleleNK Cell Lectin-Like Receptor Subfamily K, Member 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The NKG2D axis: an emerging target in cancer immunotherapy
ABSTRACT Introduction: The immunoreceptor NKG2D belongs to the best-characterized activating receptors of cytotoxic lymphocytes… 
Review
2012
Review
2012
Cancer immunotherapy using NKG2D and DNAM-1 systems.
Although tumor antigen-specific immunotherapy, such as dendritic cell vaccine, has recently emerged as a promising clinical… 
Highly Cited
2011
Highly Cited
2011
Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.
BACKGROUND & AIMS The natural killer group 2 member D (NKG2D) is a stimulatory receptor expressed on a subset of mucosal and… 
2011
2011
Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells.
BACKGROUND Engagement of Toll-like receptor (TLR) 4 on intrinsic kidney cells is critical for the full development of renal… 
2010
2010
Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus
This study aims to explore the percentage of T-cell and NK-cell subsets, the expression of NKG2A and NKG2D on CD3+ T cells and… 
Highly Cited
2009
Highly Cited
2009
Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15
IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction… 
Highly Cited
2009
Highly Cited
2009
CD8dim and NKG2D Expression Defines Related Subsets of CD4+ T cells in HIV-Infected Patients With Worse Prognostic Factors
CD4+ T lymphocytes expressing CD8dim (DP: CD4+ CD8dim) or NKG2D represent cytotoxic effector populations, which have been… 
2008
2008
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
It has been recently demonstrated that NKG2D is an activating costimulatory receptor on natural killer (NK) cells, natural killer… 
Highly Cited
2005
Highly Cited
2005
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection
The expression of the Adenovirus serotype 5 (Ad5) E1A oncogene sensitizes tumor cells to natural killer (NK) cell–mediated… 
2002
2002
Cutting Edge: The Minor Histocompatibility Antigen H60 Peptide Interacts with Both H-2Kb and NKG2D1
Minor histocompatibility Ags elicit cell-mediated immune responses and graft rejection in individuals receiving MHC-matched… 
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