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Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Although these therapies can cause dramatic tumor regressions in some… Expand
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.
A major function of NKG2D linking innate and adaptive immunity is to upregulate antigen-specific CTL-mediated cytotoxicity in tissues expressing stress-induced NKG2D ligands, such as MIC, by… Expand
Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
- Valérie Abadie, L. Sollid, L. Barreiro, B. Jabri
- Medicine, Biology
- Annual review of immunology
- 22 March 2011
Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible individuals by exposure to cereal gluten proteins. This review integrates insights from immunological… Expand
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il 10 2 / 2 mice
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Here we… Expand
Plague Bacteria Target Immune Cells During Infection
- Melanie M. Marketon, R. DePaolo, K. Debord, B. Jabri, O. Schneewind
- Biology, Medicine
- 9 September 2005
The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted… Expand
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
Under physiological conditions the gut-associated lymphoid tissues not only prevent the induction of a local inflammatory immune response, but also induce systemic tolerance to fed antigens. A… Expand
Reprogramming of CTLs into natural killer–like cells in celiac disease
- B. Meresse, S. Curran, +14 authors B. Jabri
- Biology, Medicine
- The Journal of experimental medicine
- 15 May 2006
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon γ–producing… Expand
Tissue-mediated control of immunopathology in coeliac disease
Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion… Expand
Abnormal intestinal intraepithelial lymphocytes in refractory sprue.
BACKGROUND & AIMS The etiology of refractory sprue is unclear. To gain insight into its pathogenesis, the phenotype and T-cell receptor (TCR) gene rearrangement status of intestinal lymphocytes were… Expand
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the… Expand