Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell.

@article{Bae2012ImportanceON,
  title={Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell.},
  author={Deok Sung Bae and Yu Kyeong Hwang and Jae Kwon Lee},
  journal={Cellular immunology},
  year={2012},
  volume={276 1-2},
  pages={122-7}
}
In this study, we investigate the relationship between natural killer (NK) cell susceptibility and the surface markers of cancer cells. Through phenotypic analysis, we found evidence that more susceptible cancer cell lines (K562 and Jurkat) express more NKG2D ligands. Major histocompatibility complex (MHC) class I chain-related A/B (MIC-A/B) and UL16 binding protein (ULBP) 1-5 molecules are typical ligands of NKG2D. The high killing activity of NK cells against K562 was abolished through the… CONTINUE READING

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