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J 107088

Known as: J-107088, J107088 
 
National Institutes of Health

Papers overview

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2013
2013
Various anticancer drugs, including camptothecins and indolocarbazoles, target DNA topoisomerase I (Top1). We previously… Expand
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2010
2010
Edotecarin (J-107088), a novel inhibitor of topoisomerase I has an additive effect on colon cell lines (HCT-116) when combined… Expand
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2006
2006
PurposeTo assess the maximum tolerated dose, safety, and pharmacokinetic (PK) profile of escalating doses of the novel… Expand
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2006
2006
PurposeEdotecarin (J-107088, formerly ED-749) is a potent indolocarbazole topoisomerase-I inhibitor that has the potential to… Expand
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2003
2003
In recent years, several glycosyl indolocarbazole derivatives have been developed as antitumor agents targeting the topoisomerase… Expand
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Highly Cited
2001
Highly Cited
2001
The antitumor drugs NB-506 and J-107088 are potent topoisomerase I inhibitors with an indolocarbazole structure. To clarify the… Expand
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2001
2001
Abstract. Purpose: The in vivo antitumor activity of a novel topoisomerase I inhibitor, J-107088, was tested in athymic nude mice… Expand
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Review
2000
Review
2000
  • N. Saijo
  • Annals of the New York Academy of Sciences
  • 2000
  • Corpus ID: 5638704
Abstract: CPT‐11, developed by Yakult Honsha, has achieved the position of standard chemotherapy for colorectal cancer in the… Expand
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Highly Cited
1999
Highly Cited
1999
J-107088 [6-N-(1-hydroxymethyl-2-hydroxy)ethylamino-12,13-dihydro-2,10-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a… Expand
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1999
1999
J‐107088 (6‐N‐(1‐hydroxymethyl‐2‐hydroxy)ethylamino‐12,13‐dihydro‐2,10‐dihydroxy‐13‐(β‐D‐glu‐copyranosyl)‐5H‐indolo[2,3‐a… Expand
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