Isoquinoline Alkaloid Biosynthesis Pathway

Known as: isoquinoline alkaloid formation, isoquinoline alkaloid biosynthetic process, isoquinoline alkaloid synthesis 
The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
CONTEXT Berberine, a natural plant alkaloid, is usually used as an antibiotic drug. The potential glucose-lowering effect of… (More)
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Highly Cited
2006
Highly Cited
2006
Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.
Berberine, a naturally occurring isoquinoline alkaloid, has been shown to possess anti-inflammatory and antitumor properties in… (More)
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Highly Cited
2002
Highly Cited
2002
Evolutionary origins and ecological consequences of endophyte symbiosis with grasses.
Over the past 20 yr much has been learned about a unique symbiotic interaction between fungal endophytes and grasses. The fungi… (More)
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Review
2002
Review
2002
Visualising microglial activation in vivo.
In health, microglia reside as quiescent guardian cells ubiquitously, but isolated without any cell-cell contacts amongst… (More)
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Highly Cited
2002
Highly Cited
2002
Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.
The prodrug irinotecan is an active agent for the treatment of advanced colorectal cancer and a number of other solid tumors… (More)
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2000
2000
Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica.
S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase (4'-OMT) catalyzes the conversion of 3'-hydroxy-N… (More)
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Highly Cited
1997
Highly Cited
1997
Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants
Berberine-containing plants are used medicinally in virtually all traditional medical systems, and have a history of usage in… (More)
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Highly Cited
1992
Highly Cited
1992
Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition.
The tropane alkaloid scopolamine is a medicinally important anticholinergic drug present in several solanaceous plants… (More)
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Highly Cited
1990
Highly Cited
1990
Chelerythrine is a potent and specific inhibitor of protein kinase C.
The benzophenanthridine alkaloid chelerythrine is a potent, selective antagonist of the Ca++/phospholopid-dependent protein… (More)
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Highly Cited
1990
Highly Cited
1990
Amphetamine-like effects in humans of the khat alkaloid cathinone.
1. The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be… (More)
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