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Pyrrolizidine alkaloid plants, metabolism and toxicity.
TLDR
Current information on the diagnosis, pathogenesis, and molecular mechanisms of PA toxicity is reviewed with an emphasis on the development of better diagnostics, pyrrole kinetics, and the effects of low dose PA exposure.
Current Research on Reducing Pre‐ and Post‐harvest Aflatoxin Contamination of U.S. Almond, Pistachio, and Walnut
TLDR
It was concluded that methods currently used for hand‐cracking of closed shell pistachios result in a higher risk of aflatoxin contamination, and constituents of walnut seed coat, especially from the cultivar ‘Tulare’, are potent inhibitors of a flatoxin biosynthesis, capable of rendering aflatoxigenic A. flavus virtually atxigenic.
Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation.
TLDR
Dietary constituents in certain fruits, vegetables, and spices may have significant inhibitory effects on metabolic transformation of aflatoxins to their hepatotoxic or carcinogenic derivatives or, alternatively, may promote their transformation into nontoxic products.
Honey from plants containing pyrrolizidine alkaloids: a potential threat to health.
TLDR
Observation, honey consumption data, reported levels of pyrrolizidine alkaloids in honeys, and consideration of tolerable exposure levels determined for pyrromedine alkaloid-containing plants in herbal medicines lead to the conclusion that some honey is a potential threat to health, especially for infants and fetuses, and further investigation is warranted.
Pyrrolizidine alkaloids in food: a spectrum of potential health consequences
TLDR
Growing recognition of hazardous levels of dehydroPAs in a range of common foods suggests that physicians and clinicians need to be alert to the possibility that these contaminants may, in some cases, be a possible cause of chronic diseases such as cirrhosis, pulmonary hypertension and cancer in humans.
Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae).
TLDR
Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized and alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of alpha-mannosidase with an IC(50) value of 4.6 microM.
Mycotoxins in edible tree nuts.
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