A. Elbein

Publications282
h-index52
Citations12,407
Highly Influential Citations287
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New insights on trehalose: a multifunctional molecule.
TLDR
This sugar is present in a wide variety of organisms, including bacteria, yeast, fungi, insects, invertebrates, and lower and higher plants, where it may serve as a source of energy and carbon and as a signaling molecule to direct or control certain metabolic pathways or even to affect growth.
Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains.
  • A. Elbein
  • Chemistry, Medicine
    Annual review of biochemistry
  • 1987
TLDR
A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond that are either of the complex, the high-mannose or the hybrid structure and a number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport.
Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
TLDR
Kifunensine appears to be one of the most effective glycoprotein processing inhibitors observed thus far, and knowledge of its structure may lead to the development of potent inhibitors for other processing enzymes.
Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.
  • A. Elbein
  • Medicine
    CRC critical reviews in biochemistry
  • 1984
TLDR
A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond that are either of the complex, the high-mannose or the hybrid structure and a number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport.
Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme.
TLDR
The catalytic mechanism may involve scission of the incoming disaccharide and transfer of a glucose to an enzyme-bound glucose, as [(3)H]glucose incubated with TreS and either unlabeled maltose or trehalose results in formation of [(3]H]disaccharides, suggesting that this enzyme may be valuable in carbohydrate synthetic chemistry.
Last Step in the Conversion of Trehalose to Glycogen
TLDR
It is proposed that trehalose synthase, maltokinase, and GMPMT represent a new pathway of glycogen synthesis using tre Halose as the source of glucose.
Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase.
A novel trehalase from Mycobacterium smegmatis − purification, properties, requirements
TLDR
The purified trehalase showed a single 71 kDa band on SDS gels, but active enzyme eluted in the void volume of a Sephracryl S‐300 column, suggesting a molecular mass of about 1500‰kDa or a multimer of 20 or more subunits.
The tunicamycins — useful tools for studies on glycoproteins
Abstract Inhibitors of protein glycosylation are valuable tools for various biochemical and physiological studies on the role of glycoproteins. The tunicamycin group of antibiotics have been widely…
Purification to homogeneity and properties of plant glucosidase I.
  • Y. Zeng, A. Elbein
  • Biology, Medicine
    Archives of biochemistry and biophysics
  • 1 July 1998
TLDR
The enzyme was inhibited by castanospermine, deoxynojirimycin, MDL, and trehazolin, but not by australine or kifunensine, suggesting significant differences between the plant and animal glucosidase I, in terms of catalytic site or protein conformation.
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