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- Publications
- Influence
New insights on trehalose: a multifunctional molecule.
- A. Elbein, Y. T. Pan, I. Pastuszak, D. Carroll
- Biology, Medicine
- Glycobiology
- 1 April 2003
Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an alpha,alpha-1,1-glycosidic linkage. This sugar is present in a wide variety of organisms, including bacteria,… Expand
Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains.
- A. Elbein
- Chemistry, Medicine
- Annual review of biochemistry
- 1987
A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond. These oligosaccharides may be either of the complex, the high-mannose or the hybrid structure. Each… Expand
Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
- A. Elbein, J. E. Tropea, M. Mitchell, G. Kaushal
- Biology, Medicine
- The Journal of biological chemistry
- 15 September 1990
Kifunensine, produced by the actinomycete Kitasatosporia kifunense 9482, is an alkaloid that corresponds to a cyclic oxamide derivative of 1-amino mannojirimycin. This compound was reported to be a… Expand
Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.
- A. Elbein
- Medicine
- CRC critical reviews in biochemistry
- 1984
A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond. These oligosaccharides may be either of the complex, the high-mannose or the hybrid structure. Each… Expand
Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme.
- Y. T. Pan, Vineetha Koroth Edavana, +4 authors A. Elbein
- Chemistry, Medicine
- European journal of biochemistry
- 1 November 2004
Trehalose synthase (TreS) catalyzes the reversible interconversion of trehalose (glucosyl-alpha,alpha-1,1-glucose) and maltose (glucosyl-alpha1-4-glucose). TreS was purified from the cytosol of… Expand
Last Step in the Conversion of Trehalose to Glycogen
- A. Elbein, I. Pastuszak, A. Tackett, Tyler A. Wilson, Y. T. Pan
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 29 January 2010
We show that Mycobacterium smegmatis has an enzyme catalyzing transfer of maltose from [14C]maltose 1-phosphate to glycogen. This enzyme was purified 90-fold from crude extracts and characterized.… Expand
A novel trehalase from Mycobacterium smegmatis − purification, properties, requirements
- J. Carroll, I. Pastuszak, V. K. Edavana, Y. T. Pan, A. Elbein
- Biology, Medicine
- The FEBS journal
- 1 April 2007
Trehalose is a nonreducing disaccharide of glucose (α,α‐1,1‐glucosyl‐glucose) that is essential for growth and survival of mycobacteria. These organisms have three different biosynthetic pathways to… Expand
Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase.
- A. Heifetz, R. Keenan, A. Elbein
- Chemistry, Medicine
- Biochemistry
- 29 May 1979
Purification, Cloning, Expression, and Properties of Mycobacterial Trehalose-phosphate Phosphatase*
- Stacey Klutts, I. Pastuszak, +5 authors A. Elbein
- Medicine, Biology
- The Journal of Biological Chemistry
- 24 January 2003
The trehalose-phosphate phosphatase (TPP) was purified from the cytosol of Mycobacterium smegmatis to near homogeneity using a variety of conventional steps to achieve a purification of about… Expand
Purification to homogeneity and properties of plant glucosidase I.
Glucosidase I was purified about 3600-fold to apparent homogeneity from the microsomal fraction of mung bean seedlings. The purified enzyme removed the terminal alpha1,2-linked glucose from… Expand