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Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland.
A family of five subtypes of muscarinic acetylcholine receptors (mAChR) has been identified based on their molecular structures and second signal transduction pathways. In the present study, weExpand
Development of the polymer micelle carrier system for doxorubicin.
We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugatedExpand
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
The antitumor activities of a synthetic benzo[c]phenanthridine, NK109 (7-hydroxy-2, 3-methylenedioxy-5-methyl-8-methoxybenzo[c]phenanthridinium hydrogensulfate dihydrate), and of naturalExpand
Synthesis of derivatives of NK109, 7-OH benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties.
The N5-C6 double bond of NK109 (an antitumor benzo[c]phenanthridine alkaloid) is easily reduced under biological environment. To suppress the inactivation caused by reduction, we synthesized 5-, 6-,Expand
General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.
Block copolymer micelles are nanoparticles formed from block copolymers that comprise a hydrophilic polymer such as poly(ethylene glycol) and a poorly soluble polymer such as poly(amino acids). TheExpand
Facile synthesis of 3'-O-methylthymidine and 3'-deoxythymidine and related deoxygenated thymidine derivative : a new method for selective deoxygenation of secondary hydroxy groups
This paper deals with convenient syntheses of 3'-O-methylthymidine and 3'-deoxythymidine (I) which involve Ag 2 O-promoted methylation and Barton-Robins reductive deoxygenation, respectively. NewExpand
Revision of the structure of fagaridine based on the comparison of UV and NMR data of synthetic compounds.
Fagaridine is a quaternary benzo[c]phenanthridine alkaloid, originally isolated from Fagara xanthoxyloides in 1973. The assigned structure of this alkaloid was 7-hydroxy-8-methoxy-5-methyl-2,Expand
Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.
[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The cytotoxic activity of this compound against HeLa S3 cells was strong,Expand
Improvement of drug release rate from carbopol 934P formulation.
Carbopol 934P (CP) is a mucoadhesive polymer which has been investigated as a useful adjuvant for bioadhesive drug delivery system. However, since the drug release rate from the solid formulation ofExpand