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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
- T. Chou, Steven J Brown, R. Deshaies
- Biology, ChemistryProceedings of the National Academy of Sciences
- 7 March 2011
N2,N4-Dibenzylquinazoline-2,4-diamine (DBeQ) was identified as a selective, potent, reversible, and ATP-competitive p97 inhibitor that blocks multiple processes that have been shown by RNAi to depend on p97, including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters.
NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist
Tables of 1H and 13C NMR chemical shifts have been compiled for common organic compounds often used as reagents or found as products or contaminants in deuterated organic solvents. Building upon the…
Side chain chemistry mediates backbone fragmentation in hydrogen deficient peptide radicals.
- Qingyu Sun, H. Nelson, T. Ly, B. Stoltz, R. Julian
- Biology, ChemistryJournal of proteome research
- 1 February 2009
It is shown that side chain chemistry dictates both the occurrence and relative abundance of backbone fragments that are observed, and side chain losses allow one to unambiguously narrow the possible sequences for a parent peptide, which when combined with predictable backbone fragmentation should lead to greatly increased confidence in peptide identification.
Gas phase production and loss of isoprene epoxydiols.
It is found that cis-β- and trans- β-IEPOX are the dominant isomers produced, and that they are created in an approximate ratio of 1:2 from the low-NO oxidation of isoprene.
Atmospheric autoxidation is increasingly important in urban and suburban North America
- E. Praske, Rasmus V. Otkjær, P. Wennberg
- ChemistryProceedings of the National Academy of Sciences
- 18 December 2017
The observed H-shift rate coefficients are sufficiently fast that, as a result of ongoing NOx emission reductions, autoxidation is now competing with bimolecular chemistry even in the most polluted North American cities, particularly during summer afternoons when NO levels are low and temperatures are elevated.
Synergistic O3 + OH oxidation pathway to extremely low-volatility dimers revealed in β-pinene secondary organic aerosol
- C. Kenseth, Yuanlong Huang, J. Seinfeld
- Environmental ScienceProceedings of the National Academy of Sciences
- 3 August 2018
The formation of dimers through synergistic O3 + OH oxidation represents a potentially significant, heretofore-unidentified source of low-volatility monoterpene SOA, and suggests that the current treatment of SOA formation as a sum of products originating from the isolated oxidation of individual precursors fails to accurately reflect the complexity of oxidation pathways at play in the real atmosphere.
Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators
- Judith Su, Alexander F. G. Goldberg, B. Stoltz
- Physics, ChemistryLight, science & applications
- 1 January 2016
Laser-frequency locking is used in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius, and 15.5 kDa molecules are detected in aqueous solution, thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the cell.
A comprehensive history of arynes in natural product total synthesis.
All reports of total syntheses that utilize arynes in ways that build complexity or introduce motifs essential to the completion of their targets are recounted.
The enantioselective Tsuji allylation.
The first catalytic enantioselective examples of the Tsuji allylation using enol carbonates and enol silanes are described and are useful building blocks for synthetic chemistry.
The catalytic asymmetric total synthesis of elatol.
- D. E. White, I. Stewart, R. Grubbs, B. Stoltz
- ChemistryJournal of the American Chemical Society
- 23 January 2008
What is described in this report is the first total synthesis of elatol, a halogenated sesquiterpene in the chamigrene natural product family, which represents a general platform for accessing the chAMigrenenatural product family.