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Isocitrate Dehydrogenase (NAD+)

Known as: Dehydrogenase, NAD Isocitrate, Isocitrate:NAD+ oxidoreductase (decarboxylating), Isocitrate Dehydrogenase [Chemical/Ingredient] 
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It… Expand
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Gliomas are the most common primary intracranial tumor, representing 81% of malignant brain tumors. Although relatively rare… Expand
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2012
Highly Cited
2012
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the… Expand
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… Expand
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Review
2009
Review
2009
  • R. Denton
  • Biochimica et biophysica acta
  • 2009
  • Corpus ID: 31173684
Studies in Bristol in the 1960s and 1970s, led to the recognition that four mitochondrial dehydrogenases are activated by calcium… Expand
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Highly Cited
2009
Highly Cited
2009
Somatic mutations in the IDH1 gene encoding cytosolic NADP+-dependent isocitrate dehydrogenase have been shown in the majority of… Expand
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Highly Cited
2008
Highly Cited
2008
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we… Expand
Highly Cited
1976
Highly Cited
1976
1. The activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenase were measured in muscles from a… Expand