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Isocitrate Dehydrogenase (NAD+)

Known as: Dehydrogenase, NAD Isocitrate, Isocitrate:NAD+ oxidoreductase (decarboxylating), Isocitrate Dehydrogenase [Chemical/Ingredient] 
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At present, GBMs are divided in primary and… Expand
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Review
2018
Review
2018
Glioblastoma multiforme (GBM) is a malignant tumor within the brain. Generally classified as primary and secondary with several… Expand
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Review
2018
Review
2018
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical properties. Despite advances in surgical… Expand
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Review
2017
Review
2017
Chromosomal translocations joining in-frame members of the fibroblast growth factor receptor-transforming acidic coiled-coil gene… Expand
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Review
2017
Review
2017
Primary brain tumors, most commonly gliomas, are histopathologically typed and graded as World Health Organization (WHO) grades I… Expand
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed… Expand
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Highly Cited
2008
Highly Cited
2008
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we… Expand
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