K. Aldape

Publications767
h-index127
Citations73,390
Highly Influential Citations2,990
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The Somatic Genomic Landscape of Glioblastoma
View on Elsevier
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
View on PubMed
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
View on PubMed
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
TLDR
The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
View on Nature
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
View on PubMed
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
TLDR
The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
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A randomized trial of bevacizumab for newly diagnosed glioblastoma.
TLDR
First-line use of bevacizumab did not improve overall survival in patients with newly diagnosed glioblastoma, and progression-free survival was prolonged but did not reach the prespecified improvement target.
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
View on Elsevier
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.
View on PubMed
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
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