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IDH2, human

Known as: NADP (+)-Specific ICDH, IDH2, ICD-M 
Isocitrate dehydrogenase [NADP], mitochondrial protein (452 aa, ~51 kDa) is encoded by the human IDH2 gene. This protein plays a role in intermediary… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Cells receive growth and survival stimuli through their attachment to an extracellular matrix (ECM). Overcoming the addiction to… Expand
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Highly Cited
2016
Highly Cited
2016
Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas, where they are associated with abnormal… Expand
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Highly Cited
2013
Highly Cited
2013
IDHology Among the most exciting drug targets to emerge from cancer genome sequencing projects are two related metabolic enzymes… Expand
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Highly Cited
2012
Highly Cited
2012
Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical… Expand
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Review
2012
Review
2012
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently mutated in multiple types of human cancer… Expand
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Highly Cited
2012
Highly Cited
2012
Background: NAD+-dependent deacetylase SIRT3 is essential for the prevention of age-related hearing loss during caloric… Expand
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Highly Cited
2011
Highly Cited
2011
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis… Expand
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Highly Cited
2011
Highly Cited
2011
Ollier disease and Maffucci syndrome are characterized by multiple central cartilaginous tumors that are accompanied by soft… Expand
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Highly Cited
2010
Highly Cited
2010
Background: Recently, the gene encoding the human cytosolic NADPH-dependent isocitrate dehydrogenase (IDH1) was reported… Expand
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Highly Cited
2010
Highly Cited
2010
A mutation that changes the specificity of an enzyme in human cancer is also found in an inherited metabolic disorder… Expand
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