IDH2, human

Known as: NADP (+)-Specific ICDH, IDH2, ICD-M 
Isocitrate dehydrogenase [NADP], mitochondrial protein (452 aa, ~51 kDa) is encoded by the human IDH2 gene. This protein plays a role in intermediary… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that produce the oncometabolite D-2… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2013
Highly Cited
2013
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical… (More)
Is this relevant?
Review
2012
Review
2012
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently mutated in multiple types of human cancer… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Mitochondria play a central role in oxidative energy metabolism and age-related diseases such as cancer. Accumulation of spurious… (More)
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Ollier disease and Maffucci syndrome are characterized by multiple central cartilaginous tumors that are accompanied by soft… (More)
  • figure 1
  • table 1
  • figure 2
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Heterozygous somatic mutations in the genes encoding isocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) were recently discovered… (More)
  • figure 1
Is this relevant?