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IDH2, human

Known as: NADP (+)-Specific ICDH, IDH2, ICD-M 
Isocitrate dehydrogenase [NADP], mitochondrial protein (452 aa, ~51 kDa) is encoded by the human IDH2 gene. This protein plays a role in intermediary… 
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneIDH1 wt AlleleIDH2 geneIDH2 wt Allele

Broader (1)

Isocitrate Dehydrogenase (NAD+)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Downregulation of IDH2 exacerbates H2O2-mediated cell death and hypertrophy
Objectives: Reactive oxygen species-mediated cell death contributes to the pathophysiology of cardiovascular disease and… 
2017
2017
A new functional IDH2 genetic variant is associated with the risk of lung cancer
Recently, mutations in isocitrate dehydrogenase 1/2 (IDH1/2) were discovered in 70% of low‐grade glioma and secondary… 
2017
2017
Hitting the target in IDH2 mutant AML.
In this issue of Blood, Stein et al1 demonstrate the feasibility and clinical efficacy of targeted inhibition of mutant… 
Review
2015
Review
2015
IDH2 inhibition in AML: Finally progress?
2013
2013
Snail modulates cell metabolism in MDCK cells.
2012
2012
SIRT3 Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status
Background: NAD + -dependent deacetylase SIRT3 is essential for the prevention of age-related hearing loss during caloric… 
2011
2011
Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations
Heterozygous mutations in the highly homologous genes encoding cytosolic isocitrate dehydrogenase 1 (IDH1) and mitochondrial… 
2011
2011
Construction and analyses of tetrameric forms of yeast NAD+-specific isocitrate dehydrogenase.
Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octameric enzyme composed of four heterodimers of regulatory IDH1 and… 
2010
2010
IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status
In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in… 
Highly Cited
1993
Highly Cited
1993
Kinetic analysis of NAD(+)-isocitrate dehydrogenase with altered isocitrate binding sites: contribution of IDH1 and IDH2 subunits to regulation and catalysis.
NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae is an allosterically regulated enzyme that exists as an… 
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