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Structure of the Hsp110:Hsc70 nucleotide exchange machine.
Hsp70s mediate protein folding, translocation, and macromolecular complex remodeling reactions. Their activities are regulated by proteins that exchange ADP for ATP from the nucleotide-binding domainExpand
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Structural bases of unphosphorylated STAT1 association and receptor binding.
The crystal structure has been determined at 3.0 A resolution for an unphosphorylated STAT1 (1-683) complexed with a phosphopeptide derived from the alpha chain of interferon gamma (IFNgamma)Expand
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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6
Significance Events that occur between entry of the HIV-1 capsid into the cytoplasm of the target cell and the delivery of the viral genetic material into the nucleus constitute some of the less wellExpand
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Functional requirement for symmetric assembly of archaeal box C/D small ribonucleoprotein particles.
Box C/D small ribonucleoprotein particles (sRNPs) are archaeal homologs of small nucleolar ribonucleoprotein particles (snoRNPs) in eukaryotes that are responsible for site specific 2'-O-methylationExpand
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Polycomb group targeting through different binding partners of RING1B C-terminal domain.
RING1B, a Polycomb Group (PcG) protein, binds methylated chromatin through its association with another PcG protein called Polycomb (Pc). However, RING1B can associate with nonmethylated chromatinExpand
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Sedimentation velocity analysis of highly heterogeneous systems.
This article discusses several improvements to the van Holde-Weischet (vHW) method [Biopolymers 17 (1978) 1387] that address its capability to deal with sedimentation coefficient distributionsExpand
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Structural basis of hereditary coproporphyria.
Hereditary coproporphyria is an autosomal dominant disorder resulting from the half-normal activity of coproporphyrinogen oxidase (CPO), a mitochondrial enzyme catalyzing the antepenultimate step inExpand
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Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation
Carcinoembryonic antigen (CEA)‐related cell adhesion molecules (CEACAMs) are host receptors for the Dr family of adhesins of Escherichia coli. To define the mechanism for binding of Dr adhesins toExpand
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Identification and interpretation of complexity in sedimentation velocity boundaries.
Synthetic sedimentation velocity boundaries were generated using finite-element solutions to the original and modified forms of the Lamm equation. Situations modeled included ideal single- andExpand
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The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any
The interpretation of solution hydrodynamic data in terms of macromolecular structural parameters is not a straightforward task. Over the years, several approaches have been developed to cope withExpand
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